| 5-HMF对过氧化氢诱导的人脐静脉血管内皮细胞损伤的保护作用（英文） |
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| 引用本文： | 沈亚芬,吴鑫,曹岗,蔡皓.5-HMF对过氧化氢诱导的人脐静脉血管内皮细胞损伤的保护作用（英文）[J].中国药学,2015,24(3):164-168. |
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| 作者姓名： | 沈亚芬 吴鑫 曹岗 蔡皓 |
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| 作者单位： | 浙江省中医院中药房;浙江中医药大学中药炮制技术研究中心;南京中医药大学药学院 |
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| 基金项目： | The Chinese Medicine Research Program of Zhejiang Province,China(Grant No.2014ZQ008);the Science and Technology Project of Hangzhou,China(Grant No.20130533B68,and 20131813A23);the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD,Grant No.2011ZYX2-006);the Medical Scientific Research Foundation of Zhejiang Province,China(Grant No.2013KYB183) |
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| 摘 要： | 本文主要探讨5-羟甲基糠醛(5-HMF)对过氧化氢(H2O2)诱导人脐静脉血管内皮细胞(HUVECs)损伤及凋亡的保护作用及机制。研究结果表明,5-HMF通过降低与凋亡过程直接相关的Caspase-3 and NF-κB表达,增加Bcl-2表达,从而抑制H2O2诱导人脐静脉血管内皮细胞凋亡,并降低了NO含量,减轻H2O2对内皮细胞的损伤作用。5-HMF可以缓解血管内皮细胞功能障碍和相关并发症,对血管内皮细胞具有保护作用。
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| 关 键 词： | 制山茱萸 5-羟甲基糠醛 一氧化氮 凋亡 过氧化氢 |
| 收稿时间： | 2014-12-12 |
Effect of 5-HMF on protection of hydrogen peroxide-induced injury in human umbilical vein endothelial cells |
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| Yafen Shen;Xin Wu;Gang Cao;Hao Cai.Effect of 5-HMF on protection of hydrogen peroxide-induced injury in human umbilical vein endothelial cells[J].Journal of Chinese Pharmaceutical Sciences,2015,24(3):164-168. |
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| Authors: | Yafen Shen;Xin Wu;Gang Cao;Hao Cai |
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| Institution: | Yafen Shen;Xin Wu;Gang Cao;Hao Cai;Zhejiang Provincial Hospital of TCM;Research Center of TCM Processing Technology, Zhejiang Chinese Medical University;College of Pharmacy, Nanjing University of Chinese Medicine; |
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| Abstract: | The protective effect of 5-hydroxymethylfurfural (5-HMF) against hydrogen peroxide (H2O2)-induced injured in human umbilical vein endothelial cells (HUVECs) was examined. Treatment of HUVECs with 5-HMF significantly increased their viability, decreased cell apoptosis induced by H2O2, accompanied by the decreased nitric oxide level. Western blotting analysis demonstrated that Bcl-2 expression was increased whereas Caspase-3 and NF-κB expression was decreased in 5-HMF groups. In conclusion, the results showed that 5-HMF could prevent endothelial dysfunction and related complications caused by oxidative stress. |
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| Keywords: | Processed Fructus Corni 5-Hydroxymethylfurfural Nitric oxide Apoptosis Hydrogen peroxide |
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