川贝母化学成分和药理作用研究进展及质量标志物的预测分析

川贝母为我国传统名贵药材,药用历史悠久。川贝母中含有包括生物碱、有机酸及其酯、核苷、甾醇及其苷、多糖、挥发油等多类化学成分,具有镇咳、祛痰、平喘、镇静镇痛、抗炎抗菌、抗氧化、抗肿瘤等作用。对川贝母化学成分已有研究报道的主要类型和主要药效成分的药理作用进行了系统综述。同时,基于质量标志物(Q-Marker)的概念,从药用植物亲缘学及化学成分相似性和特有性、传统功效、传统药性、现代药效研究、化学成分可测性、不同配伍及不同加工方法等方面对川贝母Q-Marker进行预测分析,建议对川贝母的贝母素甲、贝母素乙、贝母辛、西贝素及总皂苷等成分进行系统深入地分析,为川贝母质量标准的制定及评价体系的建立提供科学依据。

Research progress on chemical components and pharmacological effects and predictive analysis on quality markers of Fritillariae Cirrhosae Bulbus

Chuanbeimu (Fritillariae Cirrhosae Bulbus) is one of the traditional precious Chinese medicinal materials with a long history of medicinal use. Fritillariae Cirrhosae Bulbus contains a variety of chemical components, including alkaloids, organic acids and its esters, nucleosides, phytosterol and its glycosides, polysaccharides, volatile oil, and other components, with antitussive, expectorant, antiasthmatic, sedation and analgesia, anti-inflammatory and antibacterial, anti-oxidation, antitumor and other activities. The main types of chemical constituents and the pharmacological effects of Fritillariae Cirrhosae Bulbus were reviewed systematically. In addition, according to the concept of quality marker, the quality makers of Fritillariae Cirrhosae Bulbus were predicted and analyzed from the aspects of the phylogenetic relationship, similarity and specificity of chemical components, traditional medicinal properties, modern efficacy, measurable components, different compatibility, different processing methods and so on. It is suggested a systematic and in-depth analysis that the peimine, peiminine, peimisine, imperialine, and total saponins, which provides a scientific basis for the formulation of the quality standard and the establishment of evaluation system of Fritillariae Cirrhosae Bulbus.