Convenient and efficient synthesis of Boc‐/Z‐/Fmoc‐β‐amino acids employingN‐protected α‐amino acid fluorides |
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Authors: | K Ananda HN Gopi VV Suresh Babu |
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Abstract: | Abstract: A new and efficient method for the synthesis ofNα‐Fmoc‐/Boc‐/Z‐β‐amino acids using the two‐step Arndt‐Eistert approach is described. Fmoc‐/Boc‐/Z‐α‐Amino acid fluorides were used for the acylation of diazomethane synthesizing Fmoc‐/Boc‐/Z‐α‐aminodiazoketones as crystalline solids with good yield and purity. They were then converted to the corresponding β‐amino acids using PhCOOAg/dioxane/H2O. |
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Keywords: | acid fluoride method α ‐amino acid α ‐aminodiazoketone protected‐β ‐amino acid homologation Wolff rearrangement |
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