| 正交设计法优化复方非那沙星温度敏感型原位凝胶滴耳剂处方 |
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| 引用本文： | 孙思雨,丁海虎. 正交设计法优化复方非那沙星温度敏感型原位凝胶滴耳剂处方[J]. 海峡药学, 2019, 31(8): 7-11 |
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| 作者姓名： | 孙思雨 丁海虎 |
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| 作者单位： | 蚌埠医学院第二附属医院药剂科,安徽蚌埠,233000;蚌埠医学院基础医学部,安徽蚌埠,233000 |
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| 基金项目： | 蚌埠医学院自然科学研究项目 |
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| 摘 要： | 目的复方非那沙星温度敏感型原位凝胶滴耳剂的处方优化。方法以测定相转变温度为依据,考察不同比例的泊洛沙姆407、泊洛沙姆188、聚乙二醇6000、等基质对于凝胶性状、相转变温度等的影响。以能否获得适宜耳用的相转变温度(34℃左右)为依据,运用正交设计法筛选并确定最优处方。结果制备成有适宜相变温度的复方非那沙星温度敏感型原位凝胶滴耳剂。结论本实验确定了制备复方非那沙星温度敏感型原位凝胶滴耳剂的最优处方,且泊洛沙姆407、泊洛沙姆188、聚乙二醇6000三种基质的最佳配比为17%∶3%∶1.5%。
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| 关 键 词： | 复方非那沙星 温度敏感型原位凝胶 滴耳剂 正交试验 |
Optimization of Compound Finoxacin Temperature Sensitive In-situ Gel Ear Drops Formulation by Orthogonal Design |
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| SUN Si-yu,DING Hai-hu. Optimization of Compound Finoxacin Temperature Sensitive In-situ Gel Ear Drops Formulation by Orthogonal Design[J]. Strait Pharmaceutical Journal, 2019, 31(8): 7-11 |
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| Authors: | SUN Si-yu DING Hai-hu |
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| Affiliation: | (Pharmacy Department of the Second Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China;Department of basic medicine,Bengbu Medical College,Bengbu 233000,China) |
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| Abstract: | SUN Si-yu;DING Hai-hu(Pharmacy Department of the Second Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China;Department of basic medicine,Bengbu Medical College,Bengbu 233000,China) |
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| Keywords: | Compound non sinafloxacin Temperature sensitive in situ gel eardrops Research Orthogonal test |
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