| Caco-2细胞在药物研究中的应用进展 |
| |
| 引用本文： | 刘向峰,李娜.Caco-2细胞在药物研究中的应用进展[J].齐鲁药事,2007,26(5):293-295. |
| |
| 作者姓名： | 刘向峰 李娜 |
| |
| 作者单位： | 临沂市人民医院,山东,临沂,276003 |
| |
| 摘 要： | 目的Caco-2细胞模型特征及其在药物研究中的应用。方法概述了近年来Caco-2细胞模型在药物吸收机制、高通量筛选、药物相互作用、代谢及在药物剂型开发中应用情况。结果Caco-2细胞模型与整体吸收具有良好的相关性,可预测药物在体内的吸收、代谢规律。结论Caco-2细胞模型是药物体外研究的良好工具。
|
| 关 键 词： | Caco-2细胞模型 体外吸收 代谢 应用 |
| 文章编号： | 1672-7738(2007)05-0293-03 |
Development of Caco-2 cell model in drug researches |
| |
| LIU Xiang-feng,LI Na.Development of Caco-2 cell model in drug researches[J].qilu pharmaceutical affairs,2007,26(5):293-295. |
| |
| Authors: | LIU Xiang-feng LI Na |
| |
| Abstract: | OBJECTIVE To introduce the characteristics of Caco-2 cell model and its development in drug researches.METHODS Caco-2 cell model is widely used in the researches on drug absorption mechanism,high throughput screening,interaction and metabolism.It is also applied in the study on pharmaceutics.RESULTS The caco-2 cell model has a good correlation to the data that was obtained in vivo.It can be used to predict the absorption and metabolism of drug in vivo.CONCLUSION Caco-2 cell model is an effective tool for the research of drug in vitro. |
| |
| Keywords: | Caco-2 cell model absorption metabolism application |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
