| 食管鳞癌分化相关基因表达谱及其染色体精确定位 |
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| 引用本文： | 李沛,凌志强,杨洪艳,黄幼田,赵明耀,马俊芬,董子明.食管鳞癌分化相关基因表达谱及其染色体精确定位[J].郑州大学学报(医学版),2006,41(5):846-847. |
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| 作者姓名： | 李沛 凌志强 杨洪艳 黄幼田 赵明耀 马俊芬 董子明 |
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| 作者单位： | 郑州大学基础医学院病理生理学教研室,郑州,450052;Shiga University of Medical Science,Japan 520-2192 |
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| 基金项目： | 河南省科技攻关基金资助项目042441019 |
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| 摘 要： | 基因表达谱,结合临床病理资料筛选食管癌分化相关基因,并在染色体上精确定位。结果:与食管鳞癌分化直接相关的基因有16条,包括MET,KRT4,EGFR,KRT13,CSK,EGR1,CCND1,EPHA2,CEACAM1,PTPN2,HSPBP1,CD-KN1B,BCL2L2,SDC1,CDH1,CTNNA1;主要集中在染色体1p,2p,5q,7p,7q,11q,12p,12q,14q,15q,16q,17q,18p,19q。结论:食管鳞癌发生和演变涉及多条染色体异常的积累。
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| 关 键 词： | 食管肿瘤 基因表达谱 细胞分化 染色体异常 鳞状细胞癌 |
| 收稿时间： | 2005-09-15 |
| 修稿时间： | 2005年9月15日 |
Cell differentiation correlated genes profile and its accurate chromosome in primary esophageal squamous cell carcinoma location on tissue |
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| LI Pei,LING Zhiqiang,YANG Hongyan,HUANG Youtian,ZHAO Mingyao,MA Junfen,DONG Ziming.Cell differentiation correlated genes profile and its accurate chromosome in primary esophageal squamous cell carcinoma location on tissue[J].Journal of Zhengzhou University: Med Sci,2006,41(5):846-847. |
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| Authors: | LI Pei LING Zhiqiang YANG Hongyan HUANG Youtian ZHAO Mingyao MA Junfen DONG Ziming |
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| Institution: | 1.Department of Pathophysiology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052; 2. Shiga University of Medical Science, Japan 520-2162 |
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| Abstract: | Aim: To investigate the relationship between chromosome abnormality and cell differentiation in esophageal squamous cell carcinoma (ESCC) tissue. Methods:The genes profiles obtained from 15 cases of ESCC by cDNA microarray were analyzed and located accurately on chromosome.Results: 16 genes had significant correlation with the ESCC differentiation, and they were MET,KRT4,EGFR,KRT13,CSK,EGR1,CCND1,EPHA2,CEACAM1,PTPN2,HSPBP1,CDKN1B,BCL2L2,SDC1,CDH1, and CTNNA1,which mostly located on chromosome 1p,2p,5q,7p,7q,11q,12p,12q,14q,15q,16q,17q,18p, and 19q.Conclusion: The accumulation of more than one chromosome abnormality contributes to the carcinogenesis and progression of ESCC. |
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| Keywords: | esophageal neoplasm gene expression profile cell differentiation chromosome abnormality squamous cell carcinoma |
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