符合米氏消除药物的最优给药方案设计 |
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引用本文: | 吕淑娟 张瑞杰. 符合米氏消除药物的最优给药方案设计[J]. 哈尔滨医科大学学报, 1997, 31(2): 128-129 |
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作者姓名: | 吕淑娟 张瑞杰 |
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摘 要: | 本文讨论了药物动力学参数已生时符合米氏消除药物最优给药方案设计的一种数值方法,其特点是一次给药即可达到稳态的血药浓度。
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关 键 词: | 米氏消除 药物动力学 数值方法 给药方案设计 |
Optimal Target Dose-giving Desigcn of the Drugs Obeying Michaelis-Menten Elimination Kinetics |
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Affiliation: | Department of Mathematics |
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Abstract: | This paper consider a simple numerical method as the opcimal target dose-giving de- sign of the drugs obeying Michaelis-Menten elimination kinetics. By this method . the plasma concen- crations reach a target steady-state most quickly. |
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Keywords: | Michaelis-Menten elimirtation Pharmacokinetics Numerical method |
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