慢阻肺住院患者合并贫血、低蛋白血症调查

目的研究慢性阻塞性肺疾病(简称慢阻肺)住院患者合并贫血、低蛋白血症的患病率、及与年龄和性别的相关性研究。方法对2008年1月1日~2014年12月31日间在我院住院的患者病案数据库进行回顾性调查。结果 (1)入选慢阻肺组530人,年龄为70.95±12.94岁;对照组426人,年龄为69.34±12.34岁;两组的年龄符合正态分布。(2)慢阻肺住院患者贫血、低蛋白血症发病率是:38.1%、30.2%,高于对照组(23.0%,2.38%,P0.001)。(3)在年龄分层的贫血率比较:60~79岁慢阻肺组的发病率高于对照组的贫血的发病率(P=0.001)。(4)在贫血程度分级(P=0.531)、贫血类型构成(P=0.241)与正常人群无差异。(5)低蛋白血症在年龄分层比较,0~59岁年龄段(P=0.000),有差异,对照组主要是中度营养不良,慢阻肺组主要是轻度营养不良。60~79岁年龄段、80岁以上年龄段无差异(P=0.497,0.228)。(6)蛋白质营养不良程度构成比比较无差异(P=0.192)。(7)慢阻肺组内不同性别的低蛋白血症的发生率比较无差异(P=0.689)。(7)男性慢阻肺患者贫血患病率高于女性(P=0.000)。结论慢阻肺住院患者有较高的贫血、低蛋白血症患病率,且与年龄呈正相关;贫血严重程度、贫血的类型构成比与正常对照人群贫血构成比相同;低蛋白质血症严重程度构成比与正常对照人群低蛋白严重程度构成比相同;男性慢阻肺患者贫血患病率高于女性。

Investigation of hospitalized chronic obstructive pulmonary disease patients complicated with anemia and hy-poproteinemia

Objective To study the prevalence ratio of hospitalized chronic obstructive pulmonary disease ( COPD) patients complicated with anemia and hypoproteinemia as well as its correlation with age and gender. Meth-ods The medical record of patients admitted into our hospital from January 1st, 2008 to December 31st, 2014 in the database was retrospectively reviewed. Results (1) There were 530 cases in the COPD group with an average age of 70. 95 ± 12. 9, and 426 cases in the control group with an average age of 69. 34 ± 12. 34. (2) The incidence of ane-mia and hypoproteinemia in the COPD group was 38. 1% and 30. 2%, which were higher than that of the control group respectively(23%, 2. 38%, P<0. 001). (3) The incidence of anemia of patients at the age of 60~79 was higher in the COPD group than in the control group (P=0. 001). (4) There was no significant difference with nor-mal people in anemia grade (P=0. 531) and composition of anemia type (P=0. 241). (5) There was difference in hypoproteinemia and malnutrition only among patients at the age of 0 ~59 between the two groups. There was no difference at the age of 60~79 years old and above 80 years old (P=0. 497, 0. 228). (6) There was no difference in the constituent ratio of proteinic malnutrition degree between the COPD group and the control group (P=0. 192). (7) The difference of the hypoproteinemia incidence of different gender in the COPD group was not significant (P=0. 689). (7) The proportion of masculine anemia was higher than that of feminine anemia in the COPD group (P=0. 000). Conclusion COPD patients suffer a higher incidence of anemia and hypoproteinemia which is positively correlated with age. The constituent ratio of anemic severity and anemic type is in line with that of the normal control population. The constituent ratio of hypoproteinemia severity accords with normal control population. The incidence of masculine anemia is higher than that of feminine anemia.