特发性肺纤维化患者免疫指标检测的临床意义

目的检测特发性肺纤维化患者外周血中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-17(IL-17)的表达,探讨其与肺纤维化改变的关系。方法对49例特发性肺纤维化患者、47例健康人(正常组)以及45例普通肺炎(肺炎组)外周血中TNF-α、IL-6和IL-17表达水平进行检测。结果与正常组相比,肺炎组患者血清中IL-6、IL-17表达水平无差异,不具有统计学意义(P0.05),肺炎组血清中TNF-α表达增高,差异有统计学意义(P0.05);与正常组相比,肺纤维化组血清中IL-6、IL-17和TNF-α浓度呈明显升高趋势(P0.01);与肺炎组相比,肺纤维化血清中组IL-6、IL-17和TNF-α浓度呈明显升高趋势(P0.01)。结论 TNF-α、IL-6和IL-17表达水平与肺部纤维化改变密切相关,其表达水平对疾病诊断、治疗和预后的评估均有一定的实用价值。

Clinical significance of the serum levels of multiple immune indexes of patients with idiopathic pulmonary fi-brosis

Objective To detect the serum levels of IL-6, IL-17 and TNF-αin patients with idiopathic pul-monary fibrosis, and to study the relationship between the pulmonary fibrosis and the serum levels. Methods The serum levels of IL-6, IL-17 and TNF-αwere detected in the following three groups, the idiopathic pulmonary fibrosis group (n=49), the control group (n=47), and the common pneumonia group (n=45). Results Compared with the control group, the levels of IL-6 and IL-17 showed no statistical difference in the common pneumonia group ( P>0. 05), but the level of TNF-α increased significantly in the common pneumonia group (P<0. 05). Compared with the control group, the serum levels of IL-6, IL-17, and TNF-αincreased obviously in the idiopathic pulmonary fibro-sis group (P<0. 01). Compared with the pneumonia group, the serum levels of IL-6, IL-17, and TNF-αincreased significantly in the idiopathic pulmonary fibrosis group ( P<0. 01 ) . Conclusion The expression of TNF-α, IL-6 and IL-17 is closely related with the changes of pulmonary fibrosis, and it has certain clinical value on the assessment of diagnosis, treatment and prognosis.