广州地区5年间耐多药结核分枝杆菌药物敏感试验结果分析

目的总结耐多药结核分枝杆菌药物敏感试验结果,为制定耐多药治疗方案提供依据。方法回顾分析过去5年广州市胸科医院收治的肺结核患者,其中痰液培养结核分枝杆菌药物敏感性试验结果为耐多药的菌株共605株,按年度和除异烟肼和利福平外的其他抗结核药物的种类进行统计,比较分析,分析各种抗结核药物的耐药率以及对比五年间耐药率的变化情况。结果阿米卡星的耐药率16.86%,克拉霉素的耐药率12.89%,对氨基水杨酸异烟肼的耐药率25.29%。乙胺丁醇的耐药率63.64%,链霉素的耐药率87.27%和利福布汀的耐药率73.06%。左氧氟沙星的耐药率41.15%,莫西沙星的耐药率40.49%,丙硫异烟胺的耐药率42.81%。结论在广州地区中,阿米卡星、克拉霉素和对氨基水杨酸异烟肼的耐药率比较低。

Analysis of drug sensitivity test results of multiple drug resistance mycobacterium tuberculosis during past 5 years at Guangzhou area

Objective To analyze the drug sensitivity test results of multiple drug resistance mycobacterium tuberculosis during 5 years at Guangzhou area, in order to provide the basis for multi-drug resistant treatment. Meth-ods The clinical data of tuberculosis patients during past 5 years were retrospective analyzed. They were given spu-tum culture and drug sensitivity test, and then they were classified according to the results of anti-tuberculosis drug test, except isoniazid and rifampici. Results The resistance to amikacin was 16. 86%, 12. 89% to Clarithromycin, 25. 29% to aminosalicylic acid isoniazid, 63. 64% to ethambutal, 87. 27% to phytomycin, 73. 06% to Rifabutin, 41. 15% to Levofloxacin, 40. 49% to moxifloxacin, and 42. 81% to prothionamide. Conclusion The resistance to amikacin, Clarithromycin and aminosalicylic acid isoniazid is relatuvely low at Guangzhou area.