莫西沙星治疗耐多药肺结核的临床研究

目的研究莫西沙星治疗耐多药肺结核的临床疗效。方法选取我院收治的80例耐多药肺结核患者作为研究对象,所有患者随机分为两组:A组40例,采用莫西沙星口服,加利福喷丁、对氨基水杨酸、异烟肼口服和阿米卡星静脉给药;B组40例,左氧氟沙星及利福喷丁、对氨基水杨酸、异烟肼口服和阿米卡星静脉给药。经过4个月的治疗后,比较两组患者的血常规、血生化指标变化,临床疗效和不良反应发生情况。结果 4个月后,A组38例患者完成研究;B组39例患者完成研究。A组35例(92.11%)患者细菌阴性,35例(92.11%)患者空洞闭合,36例(94.74%)患者病灶吸收;B组26例(66.67%)患者细菌阴性,25例(64.10%)患者空洞闭合,27例(69.23%)患者病灶吸收,差异具有统计学意义(P0.05)。莫西组有效率为94.74%(36/38),左氧组有效率为79.49%(31/39),差异具有统计学意义(P0.05)。莫西组不良反应发生率为10.53%(4/38),左氧组为12.82%(5/39),差异无统计学意义(P0.05)。结论莫西沙星治疗耐多药肺结核的疗效好,安全性较为可靠。

Effect of moxifloxacin in the treatment of multi-drug resistant tuberculosis

Objective To study the effect of moxifloxacin in the treatment of multi-drug resistant tuberculo-sis. Methods 80 patients with MDR-TB were chosen as study objects, and all patients were randomly divided into two groups:40 cases in the group A ( moxifloxacin + rifapentine+isoniazid+aminosalicylate+amikacin) and 40 cases in the group B ( levofloxacin +rifapentine +isoniazid +aminosalicylate +amikacin ) . After 4 months, their blood routine, blood biochemistry, effective rate and side reactions were compared between the two groups. Results 38 patients in the group A and 39 patients in the group B completed the study. In the group A, the negative rate of bacteria was 92. 11% (35/38), the close rate was 92. 11% (35/38), and the absorption rate was 94. 74% (36/38). In the group B, the negative rate of bacteria was 66. 67% (26/39), the close rate was 64. 10% (25/39), and the absorption rate was 69. 23% (27/39) (P<0. 05). The effective rate of the group A was 94. 74% (36/38), and 69. 23% (27/39) in the group B (P<0. 05). The incidence of side reactions was 10. 53% (4/38), and 12. 82%(5/39) in the group B (P>0. 05). Conclusion Moxifloxacin has promising effect in the treatment of multi-drug resistant tuberculosis, with reliable safety.