ICU呼吸机相关性肺炎危险因素分析

目的了解ICU呼吸机相关性肺炎(Ventilator-associated pneumonia,VAP)发生的危险因素,探讨有效的干预措施。方法对本院ICU机械通气患者进行研究,共纳入206例机械通气大于48 h的患者,其中54例发生VAP,152例无VAP发生,比较VAP和非VAP两组患者在年龄、性别、基础疾病、住院时间、机械通气时间等方面的差异。结果我院ICU VAP发生率为26.21%,单因素和多因素Logistic回归分析显示高龄、机械通气时间长、ICU住院时间长、脑血管病、肿瘤术后为VAP发生的独立危险因素,早期康复治疗是VAP的保护性因素。结论 VAP由多种高危因素引起,早期康复治疗有助于预防VAP。

Analysis on risk factors of ventilator-associated pneumonia in intensive care unit

Objective To evaluate the risk factors of ventilator-associated pneumonia ( VAP) in intensive care unit, and to investigate effective strategies for this disease. Methods 206 cases with ventilation time more than 48 hours were enrolled in the study, including 54 patients with VAP and 152 non-VAP. The comparisons between the two groups on factors such as age, sex, basic diseases, hospital stay, and ventilation time, were performed to evalu-ate the effect of potential factors on development of VAP. Results The incidence of VAP in ICU was 26. 21%, and the risk factors included advanced age, long-term of ventilation, long-stay in ICU, cerebrovascular disease, and sur-gery after tumor. Early rehabilitative intervention was the protective factor for VAP. Conclusion Ventilator-associat-ed pneumonia can be caused by several high-risk factors, and early rehabilitative intervention may prevent the devel-opment of VAP.