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Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: A systematic in-depth review |
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| Authors: | Eva Boes Stefan Coassin Barbara Kollerits Iris M. Heid Florian Kronenberg |
| Affiliation: | 1. Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstrasse 41, A-6020 Innsbruck, Austria;2. Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany;3. Institute of Information Management, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich, Munich, Germany |
| Abstract: | High-density lipoprotein (HDL) particles exhibit multiple antiatherogenic effects. They are key players in the reverse cholesterol transport which shuttles cholesterol from peripheral cells (e.g. macrophages) to the liver or other tissues. This complex process is thought to represent the basis for the antiatherogenic properties of HDL particles. The amount of cholesterol transported in HDL particles is measured as HDL cholesterol (HDLC) and is inversely correlated with the risk for coronary artery disease: an increase of 1 mg/dL of HDLC levels is associated with a 2% and 3% decrease of the risk for coronary artery disease in men and women, respectively. Genetically determined conditions with high HDLC levels (e.g. familial hyperalphalipoproteinemia) often coexist with longevity, and higher HDLC levels were found among healthy elderly individuals. |
| Keywords: | HDL cholesterol Genetic association Candidate genes Systematic review Genome-wide association study |
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