光化学法建立兔视网膜分支静脉阻塞模型

目的 建立一个与临床特征和病理机制相似的新的视网膜分支静脉阻塞（branch retinal vein occlusion, BRVO）模型。 方法 5只家兔静脉内注入光化学药物孟加拉红，以波长530 nm氪绿激光照射单眼视网膜静脉分支，1 h后行荧光素眼底血管造影(fundus fluorescein angiography, FFA)检查，并于3 d后摘除5只兔眼球做病理切片。 结果 FFA检查证实5只兔眼均有BRVO，病理切片证实5只兔眼阻塞的血管内均有血栓形成。 结论 光化学法可建立和临床病理机制相似的BRVO模型，此法操作简单，为BRVO的临床研究提供了较好的动物模型。 （中华眼底病杂志，2002，18：23-25）

An animal model of branch retinal vein occlusion established by photochemical method

Objective To set up a new animal model of branch retinal vein occlusion (BRVO), which was quite similar to the clinical features and pathogenesis of this disease. Methods The animal model was set up by laser (krypton green 90 ～150 mW) irradiating a branch of central retinal vein after intravenous injection of photochemical drug (3% rose bengal) to 5 pigmented rabbits, and the model was confirmed by fundus fluorescein angiography (FFA) and pathological examination. Results The model of BRVO was successfully set up, which was confirmed by clinical examination and FFA. Pathological examination showed that the occlusion was caused by intra-venousthrombosis. Conclusion An experimental BRVO model, which has the similar pathological processes of occlusion of central retinal vein and intra-venous thrombosis as those in clinic can be set up by using photochemical method. The method is quite simple, and it offers a better animal model for clinical therapeutic research. (Chin J Ocul Fundus Dis,2002,18:23-25)