| 白细胞介素-1对病理性瘢痕成纤维细胞胶原合成的影响 |
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| 引用本文： | 杨东元,罗锦辉,朱金华. 白细胞介素-1对病理性瘢痕成纤维细胞胶原合成的影响[J]. 中华烧伤杂志, 1999, 0(6) |
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| 作者姓名： | 杨东元 罗锦辉 朱金华 |
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| 作者单位： | 第一军医大学南方医院整形科 510515广州 |
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| 摘 要： | 目的探讨细胞因子对瘢痕成纤维细胞生物学活性的调控。方法以病理性瘢痕成纤维细胞为研究对象.观察白细胞介素-1(以下简称 IL-1)对共胶原合成、核酸、超微结构的影响。结果 IL-1可以抑制病理性瘢痕成纤维细胞胶原合成及核酸的量。结论 IL-1是瘢痕调控机制中的负性调节因子,在病理性瘢痕的防治中有一定的应用价值。
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| 关 键 词： | 白细胞介索-1 瘢痕 成纤维细胞 |
The effects of IL-1 on synthesis of collagen in scar-derived fibroblasts |
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| YANG Dongyuan LUO Jinhui,ZHU Jinhua. The effects of IL-1 on synthesis of collagen in scar-derived fibroblasts[J]. Chinese journal of burns, 1999, 0(6) |
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| Authors: | YANG Dongyuan LUO Jinhui ZHU Jinhua |
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| Affiliation: | YANG Dongyuan LUO Jinhui,ZHU Jinhua Department of Plastic Surgery,Nanfang Hospital,The First Military Medical University,Guangzhou 510515 |
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| Abstract: | Objective To investigate modulation of cytokines on biological activities of scar-derived fibroblasts.Methods This study focused on the effects of interleukin-1(IL-1)on collagen biosynthesis,nu- cleic acid,and cell organs of fibroblasts.Results The results showed the IL-1 could reduce not only the collagen synthsis of fibroblasts,but also quantity of nucleic acid.Conclusion The authors confirm that IL-1 is a cytokine with down-regulation effect on scar formation,and suggest that IL-1 can play an impor- tant role in prevention and treatment of scar. |
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| Keywords: | IL-1 Scar Fibroblasts |
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