胃复春片联合复方丙谷胺西咪替丁慢性萎缩性胃炎的临床研究

目的观察胃复春片联合复方丙谷胺西咪替丁片治疗慢性萎缩性胃炎的临床疗效。方法选取2017年4月—2018年10月在三峡大学第二人民医院进行治疗的慢性萎缩性胃炎患者98例作为研究对象,将所有患者采用数字表法随机分为对照组和治疗组,每组各49例。对照组患者口服复方丙谷胺西咪替丁片,2片/次,3次/d。治疗组在对照组治疗的基础上口服胃复春片,4片/次,3次/d。所有患者均治疗4个月。观察两组患者的临床疗效,比较两组治疗前后的临床症状积分和血清学指标。结果治疗后,对照组和治疗组的总有效率分别为81.63%、93.88%,两组比较差异具有统计学意义(P0.05)。治疗后,两组胃刺痛、口干口苦、胃脘胀满、倦怠乏力和嗳气反酸评分均显著降低,同组治疗前后比较差异具有统计学意义(P0.05、0.01);且治疗后治疗组临床症状积分显著低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者胃泌素(GAS)明显下降,降钙素基因相关肽(CGRP)、血管内皮生长因子(VEGF)和一氧化氮(NO)水平均显著上升,同组治疗前后比较差异具有统计学意义(P0.05、0.01);且治疗后治疗组血清学指标显著优于对照组,两组比较差异具有统计学意义(P0.05)。结论胃复春片联合复方丙谷胺西咪替丁片治疗慢性萎缩性胃炎具有较好的临床疗效,可明显改善患者临床症状和血清学指标,具有一定的临床推广应用价值。

Clinical study of Weifuchun Tablets combined with compound proglumide and cimetidine in treatment of chronic atrophic gastritis

Objective To observe the clinical effect of Weifuchun Tablets combined with Compound Proglumide and Cimetidine Tablets in treatment of chronic atrophic gastritis. Methods Patients (98 cases) with chronic atrophic gastritis in The Second People''s Hospital of Three Gorges University from April 2017 to October 2018 were randomly divided into control and treatment groups according to number table method, and each group had 49 cases. Patients in the control group were po administered with Compound Proglumide and Cimetidine Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Weifuchun Tablets on the basis of control group, 4 tablets/time, three times daily. Patients in two groups were treatment for 4 month. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.63% and 93.88%, respectively, and there were differences between two groups (P < 0.05). After treatment, the scores of stomach prickling, dry mouth and bitter taste, epigastric fullness, belching and acid reflux in two groups were significantly decreased, and there were differences in the same group (P < 0.05, 0.01). And the clinical symptom scores in the treatment group were significantly lower than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the GAS in two groups were significantly decreased, but the CGRP, VEGF, and NO levels were increased, and the difference was statistically significant in the same group (P < 0.05, 0.01). And the serological indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P< 0.05). Conclusion Weifuchun Tablets combined with Compound Proglumide and Cimetidine Tablets has significant clinical effect in treatment of chronic atrophic gastritis, can significantly improve the clinical symptoms and serological indexes of patients, which has a certain clinical application value.