基于Arrowsmith工具探讨逍遥散抗抑郁作用机制

采用文献关联检索工具Arrowsmith从理论层面探讨逍遥散及其单味药抗抑郁的现代药理机制。利用Arrowsmith进行关联文献的检索和发现,从逍遥散单味药、整体复方及共有关联词对文献结果进行分析整理,借助Cytoscape绘图软件对逍遥散组成药材与抗抑郁作用机制进行关联性分析。逍遥散中不同的单味药可能通过调节TLR4、TRPV1、Caspase-3、PPARG、COX-2、NRF2、PI3K、ERK1、MAPK、p38 MAPK等靶点,涉及神经-内分泌-免疫等关键通路影响焦虑、束缚应激、脾虚、学习记忆等发挥抗抑郁作用。逍遥散抗抑郁的关键作用部位在海马区。逍遥散抗抑郁作用体现了中药多成分、多靶点、多途径的作用特点。通过Arrowsmith工具检索分析为深入阐释逍遥散抗抑郁作用机制提供科学依据,为中药复方研究提供研究方向和思路。

Study on mechanism of Xiaoyao Powder antidepression based on Arrowsmith tool

Using the literature retrieval tool Arrowsmith to explore the possible modern medical mechanisms of Xiaoyao Powder and single herb in the treatment of depression from the theoretical level. The related literature retrieval tool Arrowsmith was used to search and find the associated literature. The results were analyzed and summarized from the single drug, compound of Xiaoyao Powder, and common key terms. Correlation analysis between the composition of Xiaoyao Powder and the mechanism of antidepressant effect by Cytoscape tool. The results showed that different single drugs in Xiaoyao Powder may affect the nerve-endocrine-immune and other key pathways by regulating TLR4, TRPV1, Caspase-3, PPARG, COX-2, NRF2, PI3K, ERK1, MAPK, p38 MAPK, and other targets. Anxiety, restraint stress, spleen deficiency, learning, and memory play an antidepressant role. The main acting site of Xiaoyao Powder anti-depression is in the hippocampus. The antidepression effect of Xiaoyao Powder embodies the characteristics of multi-component, multi-target and multi-pathway of traditional Chinese medicine. Through Arrowsmith search, this study provides a scientific basis for further elucidating the mechanism of antidepression effect of Xiaoyao Powder, and provides research directions and ideas for the research of traditional Chinese medicine compound prescription.