| 紫草素及其衍生物抗肿瘤作用研究进展 |
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| 引用本文： | 陈阳,陈忠坚,高赟,吴永江.紫草素及其衍生物抗肿瘤作用研究进展[J].中草药,2019,50(14):3503-3509. |
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| 作者姓名： | 陈阳 陈忠坚 高赟 吴永江 |
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| 作者单位： | 浙江大学药学院, 浙江 杭州 310058,浙江省肿瘤医院, 浙江省肿瘤研究所, 浙江 杭州 310022,浙江省肿瘤医院, 浙江省肿瘤研究所, 浙江 杭州 310022,浙江大学药学院, 浙江 杭州 310058 |
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| 基金项目： | 重大新药创制科技重大专项（2018ZX09201-010） |
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| 摘 要： | 紫草素是从草本植物紫草Arnebiae Radix中提取的一种具有抗炎、抗病毒、抗肿瘤、促伤口愈合等生物活性的萘醌类化合物。近年来,紫草素及其衍生物的抗肿瘤作用被广泛研究。从构效关系、抗肿瘤作用机制等方面综述近5年紫草素及其衍生物的抗肿瘤作用的研究进展,以期为紫草素类化合物的研究及利用提供参考。
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| 关 键 词： | 紫草素 萘醌类 抗肿瘤 作用机制 构效关系 |
| 收稿时间： | 2019/4/14 0:00:00 |
Research progress on anti-tumor activity of shikonin and its derivatives |
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| CHEN Yang,CHEN Zhong-jian,GAO Yun and WU Yong-jiang.Research progress on anti-tumor activity of shikonin and its derivatives[J].Chinese Traditional and Herbal Drugs,2019,50(14):3503-3509. |
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| Authors: | CHEN Yang CHEN Zhong-jian GAO Yun and WU Yong-jiang |
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| Institution: | College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China,Department of Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China,Department of Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China and College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China |
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| Abstract: | Shikonin is a naphthoquinone compound extracted from natural plant Arnebiae Radix, which has various biological activities of anti-inflammation, antivirus, anti-tumor and promoting wound healing. The antitumor activity of shikonin and its derivatives have received widely attention in recent years. In this study, we have reviewed the advances in anti-tumor effects of shikonin and its derivatives from the aspects of structure-activity relationship and anti-tumor mechanism to provide reference for the research and utilization of shikonin in the future. |
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| Keywords: | shikonin naphthoquinones antitumor mechanism structure-activity relationship |
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