| 重楼属植物化学成分、药理作用研究进展及质量标志物预测分析 |
| |
| 引用本文： | 管鑫,李若诗,段宝忠,王莹,范敏,王双,张海珠,夏从龙. 重楼属植物化学成分、药理作用研究进展及质量标志物预测分析[J]. 中草药, 2019, 50(19): 4838-4852 |
| |
| 作者姓名： | 管鑫 李若诗 段宝忠 王莹 范敏 王双 张海珠 夏从龙 |
| |
| 作者单位： | 大理大学药学与化学学院, 云南 大理 671000,大理大学药学与化学学院, 云南 大理 671000,大理大学药学与化学学院, 云南 大理 671000;云南省高校滇西道地药材资源开发重点实验室, 云南 大理 671000,大理大学药学与化学学院, 云南 大理 671000,大理大学药学与化学学院, 云南 大理 671000,大理大学药学与化学学院, 云南 大理 671000,大理大学药学与化学学院, 云南 大理 671000;云南省高校滇西道地药材资源开发重点实验室, 云南 大理 671000,大理大学药学与化学学院, 云南 大理 671000;云南省高校滇西道地药材资源开发重点实验室, 云南 大理 671000 |
| |
| 基金项目： | 国家自然科学基金资助项目（31860080）；国家自然科学基金资助项目（81960696）；云南省地方本科高校（部分）基础研究联合专项（2017FH-001-097）；大理州区域创新能力提升专项（2018CA011-01）；大理大学中药资源与民族药创新团队项目（ZKLX2019318） |
| |
| 摘 要： | 重楼为我国传统的中药材,主要分布于我国云南、四川、贵州等地区,因其具有镇痛、止血、抗肿瘤、抗氧化、免疫调节等作用,在药品及保健品中有广泛的应用。但是其品种众多,药效差异明显,因此重楼的品质评价成为制约其开发利用亟需解决的问题之一。对重楼属植物的化学成分、药理活性进行系统整理,基于化学成分特有性、化学成分与药效相关性、传统药性、化学成分可测性几个方面对重楼属植物的质量标志物(Q-marker)进行预测分析,为该属植物的质量评价研究提供科学依据。
|
| 关 键 词： | 重楼属 质量标志物 镇痛 止血 抗肿瘤 抗氧化 |
| 收稿时间： | 2019-08-17 |
Advances in research on chemical constituents and pharmacological effects of Paris genus and prediction and analysis of quality markers |
| |
| GUAN Xin,LI Ruo-shi,DUAN Bao-zhong,WANG Ying,FAN Min,WANG Shuang,ZHANG Hai-zhu and XIA Cong-long. Advances in research on chemical constituents and pharmacological effects of Paris genus and prediction and analysis of quality markers[J]. Chinese Traditional and Herbal Drugs, 2019, 50(19): 4838-4852 |
| |
| Authors: | GUAN Xin LI Ruo-shi DUAN Bao-zhong WANG Ying FAN Min WANG Shuang ZHANG Hai-zhu XIA Cong-long |
| |
| Affiliation: | College of Pharmaceutical Science, Dali University, Dali 671000, China,College of Pharmaceutical Science, Dali University, Dali 671000, China,College of Pharmaceutical Science, Dali University, Dali 671000, China;Key Laboratory for Development of Genuine Medicinal Materials Resources Development in West Yunnan University of Yunnan Province, Dali 671000, China,College of Pharmaceutical Science, Dali University, Dali 671000, China,College of Pharmaceutical Science, Dali University, Dali 671000, China,College of Pharmaceutical Science, Dali University, Dali 671000, China,College of Pharmaceutical Science, Dali University, Dali 671000, China;Key Laboratory for Development of Genuine Medicinal Materials Resources Development in West Yunnan University of Yunnan Province, Dali 671000, China and College of Pharmaceutical Science, Dali University, Dali 671000, China;Key Laboratory for Development of Genuine Medicinal Materials Resources Development in West Yunnan University of Yunnan Province, Dali 671000, China |
| |
| Abstract: | Paridis Rhizoma is a traditional Chinese medicine, mainly distributed in Yunnan, Sichuan, Guizhou and other areas of China. Because of its analgesic, hemostatic, anti-tumor, anti-oxidant, immune regulation and other functions, it has been widely used in medicine and health products. Therefore, the quality evaluation of Paridis Rhizoma has become an urgent restriction on the development and utilization, which becomes one of the problems to be solved. In this study, the chemical constituents and pharmacological activities of Paris plants were systematically sorted out, and the quality markers of Paris plants were predicted and analyzed based on the specificity of chemical constituents, the correlation between chemical constituents and pharmacodynamics, the traditional medicinal properties and the measurability of chemical constituents, which provides scientific basis for the quality evaluation of the genus Paris. |
| |
| Keywords: | Paris L. quality marker analgesia hemostasis anti-tumor anti-oxidant |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
|
点击此处可从《中草药》下载全文 |
|
