| 青花椒根皮中1个新的香豆素类化合物 |
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| 引用本文： | 张东博,王征,梁艳妮,于金高,张珍,李铂,刘世军,蔡兴航,宋忠兴,任丽,侯青,谢培,唐志书.青花椒根皮中1个新的香豆素类化合物[J].中草药,2019,50(12):2798-2801. |
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| 作者姓名： | 张东博 王征 梁艳妮 于金高 张珍 李铂 刘世军 蔡兴航 宋忠兴 任丽 侯青 谢培 唐志书 |
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| 作者单位： | 陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083,陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083 |
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| 基金项目： | 陕西省重点研发计划（2017SF-365）；陕西省重点研发计划（2017SF-327）；陕西省教育厅自然科学专项项目（16JK1196） |
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| 摘 要： | 目的对青花椒Zanthoxylum schinifolium根皮中抗炎活性成分进行跟踪分离研究。方法采用硅胶、Sephadex LH-20、MCI以及半制备HPLC等色谱方法进行分离纯化,根据理化性质和现代谱学技术鉴定化合物的结构,以脂多糖(LPS)诱导的RAW264.7细胞炎症模型进行抗炎活性评价。结果从青花椒根皮的醋酸乙酯部位中共分离得到4个香豆素类化合物,分别鉴定为青花椒素A(1)、7-甲氧基香豆素(2)、异东莨菪内酯(3)和秦皮乙素(4)。在LPS诱导RAW264.7细胞产生一氧化氮(NO)的模型中,化合物1～4均对NO的产生具有抑制作用,半数抑制浓度(IC50)值分别为(0.21±0.03)、(0.92±0.16)、(0.15±0.02)和(0.26±0.04)μmol/L。结论化合物1为新化合物,是1个罕见的香豆素类化合物,命名为青花椒素A。化合物3为首次从该属植物中分离得到,所有化合物均具有较强的抗NO生成活性。
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| 关 键 词： | 芸香科 青花椒 青花椒素A 香豆素 抗炎活性 7-甲氧基香豆素 异东莨菪内酯 秦皮乙素 |
| 收稿时间： | 2019/2/19 0:00:00 |
A new coumarin isolated from root barks of Zanthoxylum schinifolium |
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| ZHANG Dong-bo,WANG Zheng,LIANG Yan-ni,YU Jin-gao,ZHANG Zhen,LI Bo,LIU Shi-jun,CAI Xing-hang,SONG Zhong-xing,REN Li,HOU Qing,XIE Pei and TANG Zhi-shu.A new coumarin isolated from root barks of Zanthoxylum schinifolium[J].Chinese Traditional and Herbal Drugs,2019,50(12):2798-2801. |
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| Authors: | ZHANG Dong-bo WANG Zheng LIANG Yan-ni YU Jin-gao ZHANG Zhen LI Bo LIU Shi-jun CAI Xing-hang SONG Zhong-xing REN Li HOU Qing XIE Pei and TANG Zhi-shu |
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| Institution: | Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China,Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China and Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China |
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| Abstract: | |
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| Keywords: | Rutaceae Zanthoxylum schinifolium Sieb et Zucc zantholin A coumarin anti-inflammatory activity 7-methoxycoumarin isoscopoletin esculetin |
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