色氨酸-犬尿氨酸代谢通路与神经退行性疾病及中医药干预作用的研究进展

色氨酸代谢是一个可高度调控的生理过程,犬尿氨酸通路是色氨酸代谢的主要途径,色氨酸-犬尿氨酸代谢通路涉及一系列酶促反应,代谢生成的多种生物活性物质统称为“犬尿氨酸能物质”。越来越多的研究表明,这些犬尿氨酸能物质与很多神经系统疾病的发生、发展有着密切关联,异常的色氨酸-犬尿酸代谢与诸如帕金森氏病、亨廷顿病和阿尔茨海默症等神经退行性疾病认知功能低下有关。文章就色氨酸-犬尿氨酸通路的代谢、生成的神经生物学活性物质、相关的神经系统疾病以及以此为靶点的中医药干预作用进行综述,为研究和治疗相应神经系统疾病提供一定策略与参考。

Research progress of tryptophan-kynurenine metabolic pathways and neurodegenerative diseases with intervention of traditional Chinese medicine

Tryptophan metabolism is a highly controlled physiological process,and the kynurenine pathway viewed as the main pathway for tryptophan metabolism which is involved in a series of enzymatic reactions. The metabolites generated in the process are called "kynurenine substances". More and more studies showed that the kynurenine substances are strongly related to the pathogenesis and advancement of nervous system diseases,for example,the neurodegenerative diseases including Parkinson''s disease,Huntington disease and Alzheimer''s disease. In this review,we summarized the tryptophan-kynurenine metabolic pathways,the neurobiology active substances generated in this process and relationship with the related nervous system diseases and the traditional Chinese medicine intervention on these targets with the aim to provide the strategies and hints for the therapy of nervous system diseases.