| 雷公藤甲素抗肿瘤新型给药系统研究进展 |
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| 引用本文： | 宋基正,刘宇灵,林龙飞,马红星,付赛,王秀清,李慧.雷公藤甲素抗肿瘤新型给药系统研究进展[J].中草药,2019,50(5):1269-1275. |
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| 作者姓名： | 宋基正 刘宇灵 林龙飞 马红星 付赛 王秀清 李慧 |
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| 作者单位： | 中国中医科学院中药研究所, 北京 100700,中国中医科学院中药研究所, 北京 100700,中国中医科学院中药研究所, 北京 100700,中国中医科学院中药研究所, 北京 100700;吉林农业大学, 吉林 长春 130000,中国中医科学院中药研究所, 北京 100700,中国中医科学院中药研究所, 北京 100700,中国中医科学院中药研究所, 北京 100700 |
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| 基金项目： | 国家中药标准化项目（ZYBZH-C-JL-25）；中央级公益性科研院所基本科研业务费专项资金资助（ZXKT17006）；中央级公益性科研院所基本科研业务费专项资金资助（ZXKT17050） |
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| 摘 要： | 雷公藤甲素具有广谱、高效的抗肿瘤活性,但其具有水溶性差、体内消除快和毒副作用强等缺点,限制了雷公藤甲素的临床应用。新型给药系统是靶向递送雷公藤甲素的理想载体,能够将其有效运送至肿瘤组织,提高对肿瘤的治疗效果,新型给药系统在改善雷公藤甲素溶解度、降低其毒副作用、提高生物利用度等方面有良好的应用前景。综述近10年来基于脂质体、聚合物胶束、纳米粒的雷公藤甲素抗肿瘤新型给药系统的研究进展,以期为雷公藤甲素新型给药系统在抗肿瘤药物的开发和应用等方面提供参考。
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| 关 键 词： | 雷公藤甲素 新型给药系统 抗肿瘤 脂质体 聚合物胶束 纳米粒 |
| 收稿时间： | 2018/10/19 0:00:00 |
Research progress on new drug delivery system of triptolide for anticancer therapy |
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| SONG Ji-zheng,LIU Yu-ling,LIN Long-fei,MA Hong-xing,FU Sai,WANG Xiu-qing and LI Hui.Research progress on new drug delivery system of triptolide for anticancer therapy[J].Chinese Traditional and Herbal Drugs,2019,50(5):1269-1275. |
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| Authors: | SONG Ji-zheng LIU Yu-ling LIN Long-fei MA Hong-xing FU Sai WANG Xiu-qing and LI Hui |
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| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Jilin Agricultural University, Changchun 130000, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Triptolide had broad-spectrum and high-efficient anti-cancer activity, however, its clinical application was limited by the poor water solubility, in vivo rapid elimination, and strong toxicities and side effects. New drug delivery system was the ideal vehicle for targeted delivery of triptolide, which can effectively deliver triptolide to the cancer tissue, and increase the efficiency of tumor therapy. New drug delivery system had great application prospect in improving solubility of triptolide, reducing side effect, and increasing bioavailability. This article reviewed the research progress of new drug delivery system of triptolide based on liposome, polymer micelle and nanoparticle in the past decade, providing some references for the development and application of new drug delivery system of triptolide. |
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| Keywords: | triptolide new drug delivery system antitumor activity lipidosome polymeric micelle nanoparticle |
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