醒脑静注射液联合氟马西尼治疗急性酒精中毒的疗效观察

目的探讨醒脑静注射液联合氟马西尼注射液治疗急性酒精中毒的临床疗效。方法选取2018年1月—2019年6月武警特色医学中心收治的120例急性酒精中毒患者为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组患者静脉注射氟马西尼注射液0.5 mg,如果患者在1 min内没有清醒,则再次注射0.25 mg,重复观察直至患者清醒,总量控制低于2 mg,若停药后再次昏迷,则用输液泵0.1～0.4 mg/h维持。治疗组患者在对照组治疗的基础上静脉滴注醒脑静注射液,20 mL/次,1次/d。两组患者接受治疗5 d。观察两组的临床疗效,比较两组的收缩压、心率(HR)、呼吸频率(RR)、血清酒精浓度、恢复效果。结果治疗后,对照组和治疗组的总有效率分别为85.00%、95.00%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者收缩压显著降低,HR、RR显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组患者收缩压、HR、RR显著优于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组患者酒精浓度显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组患者酒精浓度明显低于对照组,两组比较差异有统计学意义(P0.05)。治疗后,治疗组意识恢复时间和肌力恢复时间显著短于对照组,两组比较差异有统计学意义(P0.05)。结论醒脑静注射液联合氟马西尼注射液治疗急性酒精中毒具有较好的临床疗效,能降低酒精浓度,改善临床症状,安全性较好,具有一定的临床推广应用价值。

Clinical observation of Xingnaojing Injection combined with flumazine in treatment of acute alcoholism

Objective To investigate the efficacy of Xingnaojing Injection combined with Flumazenil Injection in treatment of acute alcoholism. Methods Patients (120 cases) with acute alcoholism in Armed Police Force Characteristic Medical Center from January 2018 to June 2019 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were iv administered with Flumazenil Injection 0.5 mg. If patient did not wake up within 1 min, then they were injected 0.25 mg again and observed again until the patient was awake. The total amount was less than 2 mg. If coma occured again after withdrawal, the patient would be maintained by infusion pump 0.1-0.4 mg/h. Patients in the treatment group were iv administered with Xingnaojing Injection on the basis of the control group, 20 mL/time, once daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and systolic blood pressure, HR, RR, serum alcohol concentration, and recovery effects in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.00% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the systolic blood pressures in two groups were significantly decreased, but the HR and RR in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observation indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05).After treatment, the serum alcohol concentrations in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum alcohol concentration in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, the recovery time of consciousness and muscle strength in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). Conclusion Xingnaojing Injection combined with Flumazenil Injection has clinical curative effect in treatment of acute alcoholism, can reduce alcohol concentration, and improve clinical symptoms, with good safety, which has a certain clinical application value.