| 嵌合抗原受体修饰的T细胞治疗致细胞因子释放综合征2例 |
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| 引用本文： | 涂美娟,张春丽,蒋善文,杨晓慧,方冰,王兴兵.嵌合抗原受体修饰的T细胞治疗致细胞因子释放综合征2例[J].安徽医药,2019,23(5):1054-1056. |
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| 作者姓名： | 涂美娟 张春丽 蒋善文 杨晓慧 方冰 王兴兵 |
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| 作者单位： | 中国科技大学附属第一医院(安徽省立医院)血液科,安徽 合肥,230001;中国科技大学附属第一医院(安徽省立医院)血液科,安徽 合肥,230001;中国科技大学附属第一医院(安徽省立医院)血液科,安徽 合肥,230001;中国科技大学附属第一医院(安徽省立医院)血液科,安徽 合肥,230001;中国科技大学附属第一医院(安徽省立医院)血液科,安徽 合肥,230001;中国科技大学附属第一医院(安徽省立医院)血液科,安徽 合肥,230001 |
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| 基金项目： | 安徽省科技攻关项目(1604a0802071) |
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| 摘 要： | 目的 观察嵌合抗原受体修饰的T细胞(CAR-T细胞)治疗复发难治性B细胞血液病的不良反应,探讨细胞因子释放综合征(Cytokine-Release Syndrome CRS)有效的护理措施。方法 对2例复发难治急性B细胞白血病病人应用靶向CD19的CAR-T细胞治疗时因细胞因子释放引起的一系列不良反应、治疗和护理措施进行观察及统计。结果 2例病人在接受CAR-T细胞治疗并出现细胞因子释放综合征后,经过严密的生命体征监测,积极的治疗,全方位的生活护理和心理护理,病人症状均缓解,且白血病经骨髓细胞学检查提示完全缓解。结论 细胞因子释放综合征是CAR-T治疗中最严重并发症之一,经过临床积极干预和护理后可获得良好效果。
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| 关 键 词： | 白血病 B细胞 免疫疗法 过继 嵌合抗原受体修饰的T细胞 细胞因子释放综合征 护理 |
| 修稿时间： | 2019/1/15 0:00:00 |
Two cases of cytokine releasing syndrome induced by chimeric antigen receptor modified T cells |
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| TU Meijuan,ZHANG Chunli,JIANG Shanwen,YANG Xiaohui,FANG Bing and WANG Xingbing.Two cases of cytokine releasing syndrome induced by chimeric antigen receptor modified T cells[J].Anhui Medical and Pharmaceutical Journal,2019,23(5):1054-1056. |
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| Authors: | TU Meijuan ZHANG Chunli JIANG Shanwen YANG Xiaohui FANG Bing and WANG Xingbing |
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| Institution: | Department of Hematology,The First Affiliated Hospital of USTCAnhui Provincial Hospital,Hefei,Anhui 230001,China,Department of Hematology,The First Affiliated Hospital of USTCAnhui Provincial Hospital,Hefei,Anhui 230001,China,Department of Hematology,The First Affiliated Hospital of USTCAnhui Provincial Hospital,Hefei,Anhui 230001,China,Department of Hematology,The First Affiliated Hospital of USTCAnhui Provincial Hospital,Hefei,Anhui 230001,China,Department of Hematology,The First Affiliated Hospital of USTCAnhui Provincial Hospital,Hefei,Anhui 230001,China and Department of Hematology,The First Affiliated Hospital of USTCAnhui Provincial Hospital,Hefei,Anhui 230001,China |
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| Abstract: | Objective Through The adverse reactions of CAR-T cells in the treatment of children with refractory recurrent B cells hematology applications were observed and explore Cytokine Release Syndrome (Cytokine Release Syndrome,CRS) effective nursing measures.Methods The adverse reactions,treatment and nursing measures of 2 cases of recurrence refractory acute leukemia cells B in patients treated with targeting CD19 chimeric antigen receptors modified T cells (Chimeric Antigen Receptor modified T cells,CAR-T) caused by cytokines releasing were observed.Results The 2 cases of patients,exhibiting cytokine release syndrome of aftertreated by CAR-T cells,after rigorous monitoring vital signs,the positive treatment,nursing and psychological care,a full range of life in patients with symptoms were released,and leukemia suggests complete remission by bone marrow cytology examination.Conclusion Cytokine release syndrome is a common complication.CAR-T treatment after clinical intervention and nursing can obtain good effect. |
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| Keywords: | Leukemia B-cell Immunotherapy adoptive Chimeric antigen receptor modified T cells Cytokine release syndrome Nursing |
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