| 伊马替尼药动学相关的药物相互作用研究进展 |
| |
| 引用本文： | 陈江飞.伊马替尼药动学相关的药物相互作用研究进展[J].中国现代应用药学,2019,36(12):1596-1599. |
| |
| 作者姓名： | 陈江飞 |
| |
| 作者单位： | 宁波市第一医院, 宁波 315010 |
| |
| 基金项目： | 浙江省药学会医院药学专项科研资助项目（2016ZYY25）；宁波市自然科学基金（2017A610257） |
| |
| 摘 要： | 伊马替尼是治疗慢性粒细胞白血病的一线药物,它在体内经多种CYP450代谢酶和转运体作用,临床多种合用药物可能通过不同的相互作用机制改变其在体内的过程,甚至引起显著的临床意义。本文综述并探讨了不同种类药物对伊马替尼药代动力学的影响,促进伊马替尼的临床安全、有效用药。
|
| 关 键 词： | 伊马替尼 药代动力学 药物相互作用 |
| 收稿时间： | 2018/10/22 0:00:00 |
| 修稿时间： | 2019/2/1 0:00:00 |
Advances in Drug-drug Interaction Related to Pharmacokinetics of Imatinib |
| |
| CHEN Jiangfei.Advances in Drug-drug Interaction Related to Pharmacokinetics of Imatinib[J].The Chinese Journal of Modern Applied Pharmacy,2019,36(12):1596-1599. |
| |
| Authors: | CHEN Jiangfei |
| |
| Institution: | Ningbo NO.1 Hospital, Ningbo 315010, China |
| |
| Abstract: | Imatinib, the first line treatment of chronic myelocytic leukemia, is affected by various CYP450 metabolic enzymes and transporters in pharmacokinetic process. Many clinical combination drugs may change its process in vivo by different drug-drug interaction, and even cause significant clinical significance. This article reviews and discusses the effects of different kinds of drugs on the pharmacokinetics of imatinib, so as to ensure the clinical safety and effectiveness of imatinib. |
| |
| Keywords: | imatinib pharmacokinetics drug-drug interaction |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
| 点击此处可从《中国现代应用药学》下载免费的PDF全文 |
