| 小檗碱调脂的研究进展 |
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| 引用本文： | 刘昊,周志斌. 小檗碱调脂的研究进展[J]. 现代药物与临床, 2019, 42(8): 1676-1679 |
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| 作者姓名： | 刘昊 周志斌 |
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| 作者单位： | 武汉科技大学附属天佑医院神经内科, 湖北 武汉 430064,武汉科技大学附属天佑医院神经内科, 湖北 武汉 430064 |
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| 摘 要： | 盐酸小檗碱（berberine）是从黄连中提取的一种天然的异喹啉类生物碱。小檗碱具有多种药理作用，包括抗病原微生物、抗炎、抗肿瘤、心脏保护、降血糖、调节脂质代谢以及免疫抑制等。近10年来，国内外学者对小檗碱调脂机制进行了广泛的研究。从调节血浆脂质合成、促进脂质分解等方面对小檗碱改善血脂机制加以综述，为其进一步开发和研究提供参考。
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| 关 键 词： | 小檗碱 黄连 脂质代谢 过氧化物酶体增殖物激活受体 CCAAT增强子结合蛋白 |
| 收稿时间： | 2019-01-12 |
Research progress of berberine in lipid regulating |
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| LIU Hao and ZHOU Zhibin. Research progress of berberine in lipid regulating[J]. Drugs & Clinic, 2019, 42(8): 1676-1679 |
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| Authors: | LIU Hao and ZHOU Zhibin |
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| Affiliation: | Department of Neurology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430064, China and Department of Neurology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430064, China |
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| Abstract: | Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis. Berberine has several pharmacological activities, including disease-resistant microorganisms, anti-inflammatory, anti-tumor, heart protection, hypoglycemia, regulation of lipid metabolism and immunomodulatory properties. In recent ten years,the domestic and foreign scholars have extensively studied on Lipid Regulating of berberine. In this paper, the mechanism of improving blood lipid by berberine was reviewed from the aspects of regulating plasma lipid synthesis and promoting lipid decomposition. |
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| Keywords: | berberine Coptis chinensis lipid metabolism PPARs C/EBPs |
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