| 人参皂苷Rg_3对肿瘤的免疫调节作用及其纳米给药体系研究进展 |
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| 引用本文： | 王曼,黄念,凌昌全.人参皂苷Rg_3对肿瘤的免疫调节作用及其纳米给药体系研究进展[J].中草药,2019,50(15):3729-3734. |
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| 作者姓名： | 王曼 黄念 凌昌全 |
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| 作者单位： | 海军军医大学附属长海医院中医科, 上海 200433,海军军医大学附属长海医院中医科, 上海 200433,海军军医大学附属长海医院中医科, 上海 200433 |
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| 基金项目： | 国家自然科学基金资助项目（81430101） |
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| 摘 要： | 免疫逃逸是肿瘤发生发展的重要机制,重新激活人体的抗肿瘤免疫反应是治疗恶性肿瘤的重要举措。人参皂苷Rg_3(ginsenoside Rg_3,G-Rg_3)是从人参中分离提取的一种固醇类化合物,可以通过上调肿瘤细胞自身抗原性与免疫原性、增强免疫效应细胞及免疫活性分子功能、调节局部免疫微环境等机制提高机体的抗肿瘤免疫能力。但是,水溶性差、生物利用度低等原因限制了G-Rg_3的临床应用。纳米给药体系是解决这一问题的关键。综述G-Rg_3对肿瘤的免疫调节作用及其纳米给药体系的研究进展,以期为G-Rg_3的深入研究和临床应用提供参考。
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| 关 键 词： | 人参皂苷Rg3 肿瘤 免疫 肿瘤微环境 纳米给药体系 |
| 收稿时间： | 2019/5/6 0:00:00 |
Immunomodulatory effects of ginsenoside Rg3 on tumors and its nano-drug delivery system |
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| WANG Man,HUANG Nian and LING Chang-quan.Immunomodulatory effects of ginsenoside Rg3 on tumors and its nano-drug delivery system[J].Chinese Traditional and Herbal Drugs,2019,50(15):3729-3734. |
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| Authors: | WANG Man HUANG Nian and LING Chang-quan |
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| Institution: | Department of Traditional Chinese Medicine, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai 200433, China,Department of Traditional Chinese Medicine, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai 200433, China and Department of Traditional Chinese Medicine, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai 200433, China |
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| Abstract: | Immune escape is an important mechanism for the development of tumors. Re-activating the anti-tumor immune response is a key measure for the treatment of malignant tumors. Ginsenoside Rg3 (G-Rg3) is a sterol compound isolated from Panax ginseng. It can improve the anti-tumor immune response of human by up-regulating the autoantigenicity and immunogenicity of tumor cells, enhancing the function of immune effector cells and immune active molecules, and regulating the local immune microenvironment. However, the clinical application of G-Rg3 is limited due to its poor water solubility and low bioavailability. Improved drug delivery systems are the key to solving this problem. Therefore, this paper summarizes the research progress of G-Rg3 on tumor immunoregulation and its nano-drug delivery systems, in order to provide reference for the in-depth study and clinical application of G-Rg3. |
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| Keywords: | ginsenoside Rg3 tumor immunology tumor microenvironment nano-drug delivery system |
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