| 多指标综合评分法优选芩黄凝胶剂提取工艺 |
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| 引用本文： | 林雄,严国鸿,潘旭东,黄燕. 多指标综合评分法优选芩黄凝胶剂提取工艺[J]. 中国现代应用药学, 2019, 36(12): 1502-1507 |
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| 作者姓名： | 林雄 严国鸿 潘旭东 黄燕 |
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| 作者单位： | 福建中医药大学附属人民医院, 福州 350004,福建中医药大学附属人民医院, 福州 350004,福建中医药大学附属人民医院, 福州 350004,福建中医药大学附属人民医院, 福州 350004 |
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| 基金项目： | 福建省科技厅引导性项目（2017Y0045） |
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| 摘 要： | 目的 优选芩黄凝胶剂的提取工艺。方法 以黄芩苷、芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚的转移率为评价指标，采用L9（34）正交法优选芩黄凝胶剂的水提取与醇提取工艺。结果 最佳水提取工艺为加6倍量水，浸泡0.5 h，回流提取2次，每次提取1.5 h；最佳醇提取工艺为加8倍量40%乙醇，回流提取3次，每次提取1.0 h。结论 采用多指标综合评分法优选的芩黄凝胶剂提取工艺合理、可行。
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| 关 键 词： | 芩黄凝胶剂 提取工艺 正交试验 黄芩苷 大黄蒽醌 |
| 收稿时间： | 2018-08-30 |
| 修稿时间： | 2018-12-01 |
Optimization for Extraction Technology of Qinhuang Gel by Multicreteria Comprehensive Assessment |
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| LIN Xiong,YAN Guohong,PAN Xudong and HUANG Yan. Optimization for Extraction Technology of Qinhuang Gel by Multicreteria Comprehensive Assessment[J]. The Chinese Journal of Modern Applied Pharmacy, 2019, 36(12): 1502-1507 |
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| Authors: | LIN Xiong YAN Guohong PAN Xudong HUANG Yan |
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| Affiliation: | The Affiliated People''s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China,The Affiliated People''s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China,The Affiliated People''s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China and The Affiliated People''s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China |
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| Abstract: | OBJECTIVE To optimize the extraction technology of Qinhuang gel. METHODS With the transferring rate of baicalin, aloe emodin, rhein, emodin, chrysophanol, physcion as index, orthogonal design L9(34) was carried out for the optimum extraction technology of Qinhuang gel by water and ethanol. RESULTS The optimum extraction technology by water were as follows:6-fold water, soaking 0.5 h, reflux extracting 2 times and 1.5 h each time; the optimum extraction technology by ethanol were as follows:8-fold 40% ethanol, reflux extracting 3 times and 1.0 h each time. CONCLUSION The extraction technology of Qinhuang gel optimized by multicreteria comprehensive assessment is reasonable and practical. |
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| Keywords: | Qinhuang gel extraction technology orthogonal design baicalin anthrquinone of rhubarb |
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