苦参碱抗乳腺癌和卵巢癌的药理作用研究进展

苦参碱能呈剂量相关地抑制乳腺癌MCF-7细胞、Bcap-37细胞、MA737细胞、Walker256细胞、TM40D细胞、4T1细胞、SK-BR-3细胞、MDA-MB-231细胞，以及卵巢癌NuTu19细胞、SKOV3细胞、A21-2细胞、OV2008细胞、HO-8910PM细胞、PA-1细胞、PM-2细胞、3AO细胞、OVCAR3细胞生长并诱导凋亡。苦参碱是这些癌细胞的自噬早期诱导剂，更是自噬晚期抑制剂，通过诱导线粒体凋亡和内质网应激的2个途径引起癌细胞凋亡的，因而能提高癌细胞对放、化疗的敏感性。苦参碱增强机体的免疫调节功能也是其抗癌作用机制的一部分，并能对抗放化疗抑制免疫的毒副作用发生。

Research advances of matrine against mammary cancer and ovarian car

Matrine inhibits proliferation and induces apoptosis in association with dosage on mammary cancer MCF-7 cells, Bcap-37 cells, MA737 cells, Walker 256 cells, TM40D cells, 4T1 cells, SK-BR-3 cells, MDA-MB-231 cells, and ovarian carcinoma NuTu19 cells, SKOV3 cells, A21-2 cells, OV2008 cells, HO-8910PM cells, PA-1 cells, PM-2 cells, 3AO cells, OVCAR3 cells. Matrine is a inducer of early stage of autophagy, and is more a inhibitor of late stage of autophagy. Matrine induces the apoptosis of these cancer cells by two pathways of mitochondria apoptosis and endoplasmic reticulum stress. Matrine enhances sensitivity of cancer cells to radiotherapy and chemotherapy. The immunoenhancement of matrine is its mechanism of antitumor too, and can antagonize occurrence of immunodepression in radiotherapy and chemotherapy.