2016—2017年焦作市第二人民医院中药注射剂不良反应分析

目的 了解焦作市第二人民医院中药注射剂不良反应（ADR）发生情况，分析、总结不良反应特点及规律，为临床合理用药提供参考。方法 收集焦作市第二人民医院2016年1月—2017年12月因使用中药注射剂致ADR 176例，进行统计、分析。结果 中药注射剂不良反应分布广泛且以老年人居多，女性多于男性，引发ADR例数最多的为注射用血塞通，有32例，构成比为18.18%。由西医师开具医嘱的为118例，占67.05%。已知一般的ADR有101例（57.39%），累及器官或（和）系统以皮肤及其附件损害最多，有82例（41.41%）。用药后11～30 min内发生ADR最为常见，构成比为32.95%。共发现严重不良反应5例，占全部ADR的2.84%。结论 应对使用中药注射剂的患者密切观察，做好防范措施，同时应做好不良反应监测，规范医生合理用药，避免或减少不良反应的发生。

Analysis on adverse reactions induced by traditional Chinese medicine injections in the Second People's Hospital of Jiaozuo from 2016 to 2017

Objective To learn the adverse drug reaction (ADR) of traditional Chinese medicine injection in the Second People''s Hospital of Jiaozuo, to analyze and summarize the characteristics and regularities of ADR, and in order to provide reference for clinical rational use of drugs. Methods ADR (176 cases) induced by traditional Chinese medicine injections in the Second People''s Hospital of Jiaozuo from January 2016 to December 2017 were collected, and were retrospectively analyzed. Results ADR induced by traditional Chinese medicine injection was widely distributed, and most were the elderly. Females with ADR of traditional Chinese medicine injection were more than males. Sanqi Panax Notoginseng for injection had the most ADR (32 cases), accounting for 18.18%. There were 118 cases (67.05%) of ADR ordered by western doctors. Known and general ADR was common (101 cases, 57.39%). The main organs/systems involved in the cases were the lesion of skin and its appendages (82 cases, 41.41%). Most of the adverse drug reactions happened in 11-30 min (32.95%). There were 5 cases of serious ADR, accounting for 2.84%. Conclusion Patients used Chinese medicine injections should be closely observed, and precautions of ADR should be taken, and at the same time, the monitoring of ADR should be strengthened and regulate the rational use of drug by doctors for avoidance or reduction of ADR.