活性氧在牙周炎中病理作用的研究进展

牙周炎是一种常见的慢性炎症疾病,引起牙周组织的损伤,受损部位包括牙龈、牙周韧带和牙槽骨。引发牙周炎的主要原因是人体对口腔微生物及其代谢产物的免疫反应,其中活性氧(ROS)的稳态失衡和抗氧化防御系统在牙周炎的发病进程中扮演了重要的促进角色。升高的ROS引发病灶组织细胞的自噬,导致相应的组织细胞凋亡,进一步阐明牙周炎自噬过程中氧还原调控的作用和机制,对牙周病治疗策略的研究具有一定的临床指导意义。笔者对ROS在牙周炎中的相关病理作用做了简要综述。

Progress in the pathologic role of active oxygen in periodontitis

Periodontitis is a chronic inflammatory disease that causes injury in periodontal tissues,including gum,periodontal ligament and alveolar bone.The main cause of periodontal tissue destruction is the host immune response to oral microbes and their metabolites,in which the steady-state imbalance of reactive oxygen species and the antioxidant defense system play an important role.Increased reactive oxygen species induce autophagy,leading to apoptosis of the corresponding tissue.To further elucidate the role and mechanism of oxygen reduction in autophagy of periodontitis,and to study the therapeutic strategies of periodontal disease has certain clinical significance.In this article,we briefly reviewed the related pathological effects of ROS on periodontitis.