大黄化学成分、药理作用研究进展及质量标志物的预测分析

大黄是我国传统常用的中药材,功效独特且资源丰富,主要分布在亚温带及亚热带的高寒山区,其道地产区为我国甘肃、四川、西藏等高海拔地区。近年来,随着国内外学者对大黄全方位深入探究,其多类型的化学成分与广泛的药理作用及应用开发研究备受关注。在对大黄化学成分、传统功效、现代药理作用分析的基础上,根据质量标志物概念,从化学成分与传统药性、传统功效、临床新用途相关性、入血成分、可测成分、不同配伍中显效成分及贮藏时间影响等多方面对大黄质量标志物进行预测分析,为大黄质量评价体系的建立提供参考。

Research progress on chemical composition and pharmacological effects of Rhei Radix et Rhizoma and predictive analysis on quality markers

Rhei Radix et Rhizoma is a kind of traditional Chinese medicinal material in China, which has unique efficacy and rich resources. It is mainly distributed in the alpine mountains of temperate and subtropical Asia. Its genuine producing areas are Gansu Province, Qinghai Province, Sichuan Province, and Tibet Autonomous Region. In recent years, with the continuous in-depth study of Radix et Rhizoma by scholars at home and abroad, many kinds of chemical constituents, extensive pharmacological effects and application and development of Radix et Rhizoma have attracted much attention, and have broad application prospects and considerable market value. Based on the analysis of its chemical composition and traditional efficacy combined with modern pharmacological action, and according to the theory of quality marker, the quality markers of Radix et Rhizoma were predicted and analyzed from the aspects of the chemical composition and traditional medicinal properties, traditional efficacy, new clinical uses, plasma composition, measurable components, effective components in different compatibility, and the effect of storage time and so on, which provides a scientific basis for the quality evaluation of Radix et Rhizoma and establishment of its quality control system.