ACI患者颈动脉粥样硬化斑块与hs- CRP、FBG及HCY的关系分析

目的：探讨急性脑梗死(ACI)患者颈动脉粥样硬化斑块与hs- CRP、FBG及HCY的关系。方法 以2014年3月-2015年8月在我院接受治疗的60例急性脑梗死患者为观察对象,其中斑块组25例,非斑块组35例。同时选取60例体检健康的成年人作为对照组。比较两组一般资料的差异,观察ACI组和对照组以及斑块组和非斑块组hs- CRP、FBG及HCY水平的差异,分析颈动脉粥样硬化斑块形成的危险因素。结果 ACI组患者的hs- CRP、FBG及HCY水平明显高于对照组,差异具有统计学意义(P<0.05)；斑块组患者hs- CRP、FBG及HCY水平,明显高于非斑块组,差异具有统计学意义(P<0.05)；斑块组患者TG和LDL-C水平明显高于非斑块组(P<0.05),而两组患者的TC、HDL-C水平无明显差别(P>0.05)；将患者的一般资料、血脂水平、hs- CRP、FBG 及HCY水平作为自变量,将ACI患者是否合并斑块作为因变量进行Logistic回归分析。结果显示hs- CRP、HCY水平是ACI患者颈动脉粥样硬化斑块形成的危险因素(OR=4.315、5.208和4.553)。结论 急性脑梗死患者颈动脉硬化斑块的形成与hs- CRP、HCY水平密切相关,可作为临床监测的重要指标。

Analysis of the relationship between carotid atherosclerotic plaque and hs-CRP , FBG and HCY in patients with ACI

Objective To investigate the relationship between carotid atherosclerotic plaque and CRP hs-, FBG and HCY in patients with acute cerebral infarction (ACI). Methods 60 patients with acute cerebral infarction treated in our hospital from March 2014 to August 2015 were observed, including 25 cases of plaque group and 35 cases of non plaque group. At the same time, 60 healthy adults were selected as the control group. The differences between the two groups were compared, and the differences of hs-CRP, FBG and HCY levels between the ACI group and the control group as well as the plaque group and non plaque group were observed, and the risk factors of carotid atherosclerotic plaque formation were analyzed. Results CRP FBG, hs- and HCY levels in ACI group were significantly higher than those in control group, and the difference was statistically significant (P<0.05); hs-CRP , FBG and HCY levels were significantly higher in the plaque group than in the non plaque group (P<0.05), and the difference was statistically significant (P<0.05); The level of TG and LDL-C in the plaque group was significantly higher than that in the non plaque group (P<0.05), while there was no significant difference in the level of HDL-C and TC between the two groups (P>0.05); The general information of patients, blood lipid levels, CRP FBG, hs- and HCY levels as independent variables, the ACI patients with plaque as a result of Logistic regression analysis of the variables. The results showed that the levels of CRP HCY and hs- were the risk factors for carotid atherosclerotic plaque formation in ACI patients (OR=4.315, 5.208 and 4.553). Conclusion The formation of carotid atherosclerotic plaque in patients with acute cerebral infarction is closely related to the level of CRP HCY and hs-, which can be used as an important indicator for clinical monitoring.