0.01%次氯酸局部滴眼治疗细菌性角膜溃疡的临床分析

目的：评估0.01%次氯酸在细菌性角膜溃疡治疗中的作用。

方法：选取2018-08/12在徐州医科大学附属医院眼科就诊的细菌性角膜溃疡患者共60例60眼，随机分为2组，常规治疗组给予左氧氟沙星滴眼液治疗30例30眼，联合用药组在常规治疗的基础上加用0.01%次氯酸水溶液局部滴眼，观察比较两组患者的治疗效果。

结果：联合用药组溃疡愈合时间明显短于常规治疗组(P=0.005)，但两组治愈率(P=0.643)、最佳矫正视力(P=0.787)无差异。两组患者出现虹膜睫状体炎发生率无差异(P=0.643)。两组均未出现角膜穿孔、角膜新生血管等并发症，联合用药组患者使用0.01%次氯酸滴眼无明显角膜刺激症状。

结论：0.01%次氯酸局部滴眼能加快细菌性角膜溃疡的愈合速度，且无严重并发症出现。

Clinical analysis of 0.01% hypochlorous acid eye drops in the treatment of bacterial corneal ulcer

AIM:To evaluate the role of 0.01% hypochlorous acid in the treatment of bacterial corneal ulcer.

METHODS: A total of 60 eyes of 60 patients with bacterial corneal ulcer who were admitted to the Department of Ophthalmology, the Affiliated Hospital of Xuzhou Medical University from August to December 2018 were randomly divided into control group and combined treatment group, 30 cases in each group. The control group was treated with antibiotic eye drops. The combined treatment group was treated with 0.01% hypochlorous acid aqueous solution on the basis of conventional treatment. The therapeutic effects of the two groups were observed and compared.

RESULTS: The ulcer healing time was significantly shortened in the combination group(P=0.005). However, there was no significant difference between the two groups in cure rate(P=0.643)and final visual acuity(P=0.787). There was a small number of patients with iridocyclitis in both groups, and the incidence was not statistically different(P=0.643). There were no complications such as corneal perforation and corneal neovascularization in both groups. Patients in the combination group had no obvious corneal irritation with 0.01% HOCI eye drops.

CONCLUSION: 0.01% hypochlorous acid eye drops can accelerate the healing rate of bacterial corneal ulcer without serious complications, indicating a promising future in the field of corneal ulcer treatment.