胃疡宁丸联合瑞巴派特片治疗胃溃疡活动期的临床研究

目的探讨胃疡宁丸联合瑞巴派特片治疗胃溃疡活动期患者的临床疗效。方法选取2018年1月—2018年12月在中国人民解放军联勤保障部队第九八九医院治疗的胃溃疡活动期患者124例,随机分为对照组和治疗组,每组各62例。对照组口服瑞巴派特片,0.1 g/次,3次/d。治疗组在对照组基础上口服胃疡宁丸,3.0 g/次,3次/d。两组患者均治疗8周。观察两组患者临床疗效,同时比较治疗前后两组患者幽门螺杆菌(Hp)根除率及血清C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-8(IL-8)、胃泌素(GAS)、生长抑素(SS)、血管内皮生长因子(VEGF)和前列腺素E2(PGE2)水平。结果治疗后,对照组和治疗组临床有效率分别为79.03%和93.55%,两组比较差异有统计学意义(P0.05)。治疗后,对照组Hp根除率为77.42%,显著低于治疗组的91.94%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者血清CRP、PCT、IL-8、GAS、SS水平均显著降低(P0.05),而VEGF和PGE2水平显著升高(P0.05),且治疗组这些血清指标明显好于对照组,两组比较差异具有统计学意义(P0.05)。结论胃疡宁丸联合瑞巴派特片治疗胃溃疡活动期有更高的溃疡愈合率及幽门螺杆菌根除率,能有效的降低血清炎症因子。

Clinical study on Weiyangning Pills combined with Rebamipide Tablets in treatment of active gastric ulcer

Objective To investigate the clinical effects of Weiyangning Pills combined with Rebamipide Tablets in treatment of active gastric ulcer. Methods Patients (124 cases) with active gastric ulcer in the 989 Hospital of the Joint Logistics Support Force of the Chinese People''s Liberation Army from January 2018 to December 2018 were randomly divided into control and treatment groups, and each group had 62 cases. Patients in the control group were po administered with Rebamipide Tablets, 0.1 g/time, three times daily. Patients in the treatment group were po administered with Weiyangning Pills on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the Hp eradication rates, and serum levels of CRP, PCT, IL-8, GAS, SS, VEGF, and PGE2 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 79.03% and 93.55%, respectively, and there were differences between two groups (P<0.05). After treatment, the Hp eradication rate in the control group was 77.42%, which was significantly lower than 91.94% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the serum levels of CRP, PCT, IL-8, GAS, SS, VEGF, and PGE2 in two groups were significantly decreased (P<0.05), but VEGF and PGE2 levels were significantly increased (P<0.05), and these serum indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Weiyangning Pills combined with Rebamipide Tablets in treatment of active gastric ulcer has the higher ulcer healing rate and Hp eradication rate, can decreases of the serum inflammatory factor.