| 胆囊结石与遗传因素 |
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| 引用本文： | 张峰铭,金盛哲,葛春林.胆囊结石与遗传因素[J].安徽医药,2019,23(8):1492-1495. |
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| 作者姓名： | 张峰铭 金盛哲 葛春林 |
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| 作者单位： | 中国医科大学附属第一医院胰胆外科,辽宁 沈阳,110000;金日成综合大学,朝鲜 平壤,999093 |
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| 摘 要： | 胆囊结石是最常见的胆管疾病,也是最常见的消化道疾病之一。胆囊结石在发展中国家的发病率逐年提高,已经成为世界范围内第二常见的胃肠道疾病。流行病学研究提示,胆囊结石的形成与多种遗传因素和环境因素相关。人们通过连锁分析家系和种族研究探索遗传因素对胆囊结石形成起到的作用。越来越多的证据表明遗传因素对胆囊结石的形成起到了至关重要的作用。
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| 关 键 词： | 胆囊结石病 疾病遗传易感性 多态现象 遗传 胆固醇酯转运蛋白质类 受体 胆囊收缩素A 基因 |
| 收稿时间： | 2018/1/2 0:00:00 |
| 修稿时间： | 2018/1/31 0:00:00 |
Gallstone and genetic factors |
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| ZHANG Fengming,JIN Shengzhe and GE Chunlin.Gallstone and genetic factors[J].Anhui Medical and Pharmaceutical Journal,2019,23(8):1492-1495. |
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| Authors: | ZHANG Fengming JIN Shengzhe and GE Chunlin |
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| Institution: | Department of Pancreaticobiliary Surgery,The First Hospital of China Medical University, Shenyang,Liaoning 110000,China,Kim Il-sung University,Pyongyang 999093,North Korea and Department of Pancreaticobiliary Surgery,The First Hospital of China Medical University, Shenyang,Liaoning 110000,China |
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| Abstract: | Gallstone disease is one of the most common biliary tract disorders worldwide and also one of the most common gastrointestinal disorders.The morbidity of gallstone disease is increasing with each passing year in developing countries and has become the second common gastrointestinal disorder.Epidemiologic studies have implicated that multiple environmental factors and genetic elements involve in gallstone formation.Genetic factors that influence gallstone formation have been elaborated from linkage studies,families,and ethnicities.Accumulating evidence indicates that genetic factors play an important role in gallstone disease. |
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| Keywords: | Cholecystolithiasis Genetic predisposition to disease Polymorphism genetic Cholesterol ester transfer proteins Receptor cholecystokinin A Genetics Genes |
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