固肾安胎丸联合阿司匹林治疗复发性流产的临床研究

目的探讨固肾安胎丸联合阿司匹林肠溶片治疗复发性流产的临床疗效。方法选取2016年2月—2018年2月郑州大学第三附属医院收治的复发性流产患者100例作为研究对象,采用随机数字表法将所有患者随机分为对照组和治疗组,每组各50例。对照组患者在妊娠12周左右口服阿司匹林肠溶片,100 mg/次,1次/d;治疗组在对照组治疗的基础上口服固肾安胎丸,1袋/次,3次/d。两组患者均持续治疗12周。观察两组患者的临床疗效,同时比较两组患者的性激素水平、凝血指标水平和妊娠结局。结果治疗后,治疗组患者的总有效率为92.00%,显著高于对照组的82.00%,两组总有效率比较差异具有统计学意义(P0.05)。治疗后,两组患者的人绒毛膜促性腺激素(HCG)、雌二醇(E2)和孕酮(P)水平均显著升高,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组性激素水平显著高于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者的纤维蛋白原(FIB)、纤溶酶原激活物抑制物1(PAI-1)水平均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组的凝血指标水平显著低于对照组,两组比较差异具有统计学意义(P0.05)。两组患者凝血酶时间(TT)和凝血酶原时间(PT)治疗前后比较无差异。治疗后,对照组和治疗组的活产率分别为82.00%、92.00%,两组比较差异具有统计学意义(P0.05)。结论固肾安胎丸联合阿司匹林肠溶片治疗复发性流产具有较好的临床疗效,能够改善患者的性激素水平和血液高凝状态,安全性较高,具有一定的临床推广应用价值。

Clinical study on Gushen Antai Pills combined with aspirin in treatment of recurrent abortion

Objective To investigate the clinical efficacy of Gushen Antai Pills combined with Aspirin Enteric-coated Tablets in treatment of recurrent abortion. Methods Patients (100 cases) with recurrent abortion in the Third Affiliated Hospital of Zhengzhou University from February 2016 to February 2018 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Aspirin Enteric-coated Tablets at 12 weeks of gestation, 100 mg/time, once daily. Patients in the treatment group were po administered with Gushen Antai Pills on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the sex hormone levels, coagulation indexes, and pregnancy outcomes in two groups were compared. Results After treatment, the clinical efficacy in the treatment group was 92.00%, which was significantly higher than 82.00% in the control group, and there were differences between two groups (P < 0.05). After treatment, HCG, E₂, and P levels in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the sex hormone levels in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, FIB and PAI-1 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, coagulation indexes levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). There was no significant difference in TT and PT between two groups. After treatment, the live birth rates in the control and treatment groups were 82.00% and 92.00%, respectively, and there was difference between two groups (P < 0.05). Conclusion Gushen Antai Pills combined with Aspirin Enteric-coated Tablets has a good clinical effect in the treatment of recurrent abortion, can improve the levels of sexual hormones and blood hypercoagulation status of patients, with high safety, which has a certain clinical application value.