活血止痛胶囊联合依托考昔治疗膝关节骨性关节炎的疗效观察

目的探讨活血止痛胶囊联合依托考昔治疗膝关节骨性关节炎的临床疗效。方法选取选取2016年2月—2017年2月天津中医药大学第一附属医院骨伤科膝关节骨性关节炎患者60例,随机分为对照组和治疗组,每组各30例。对照组患者饭后口服依托考昔片,1片/次,1次/d。治疗组在对照组治疗基础上口服活血止痛胶囊,6粒/次,2次/d。两组均连续治疗4周。观察两组的临床疗效,比较两组治疗前后VAS评分、WOMAC评分、Lysholm评分、Lequesne指数、患肢红外热成像温度的变化情况。结果治疗后,对照组和治疗组的总有效率分别为86.67%、96.67%,两组比较差异具有统计学意义(P0.05)。治疗后,两组VAS评分、WOMAC评分和Lequesne指数均较治疗前显著降低,Lysholm评分较治疗前显著升高,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组VAS评分、WOMAC评分和Lequesne指数低于对照组,Lysholm评分高于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组患膝红外热成像温度均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P0.05);治疗后治疗组患膝红外热成像温度低于对照组,两组比较差异有统计学意义(P0.05)。结论活血止痛胶囊联合依托考昔治疗膝关节骨性关节炎具有较好的临床疗效,能减轻患者膝关节疼痛和改善膝关节功能,降低患膝红外热成像温度,具有一定的临床推广应用价值。

Clinical observation on Huoxue Zhitong Capsules combined with etoricoxib in treatment of knee osteoarthritis

Objective To investigate the clinical effect of Huoxue Zhitong Capsules combined with etoricoxib in treatment of knee osteoarthritis. Methods Patients (60 cases) with knee osteoarthritis in the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from February 2016 to February 2017 were randomly divided into control (30 cases) and treatment (30 cases) groups. Patients in the control group were po administered with Etoricoxib Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Huoxue Zhitong Capsules on the basis of the control group, 6 grains/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of VAS score, WOMAC score, Lysholm score, Lequesne index, and infrared thermal imaging temperature of the affected limb in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 86.67% and 96.67%, respectively, and there were differences between two groups (P < 0.05). After treatment, VAS score, WOMAC score, and Lequesne index in two groups were significantly decreased, but Lysholm score was significantly increased, and there were differences in the same group (P < 0.05). After treatment, VAS score, WOMAC score, and Lequesne index in the treatment group were lower than those in the control group, but Lysholm score was higher than that in the control group, and there were differences between two groups (P < 0.05). After treatment, the infrared thermal imaging temperature of both groups was significantly lower than that before treatment, and there were differences in the same group (P < 0.05). After treatment, the infrared thermal imaging temperature in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Huoxue Zhitong Capsules combined with etoricoxib has significant effect in treatment of knee osteoarthritis, and can reduce knee joint pain and improve knee joint function, and also can reduce the infrared thermal imaging temperature of the affected knee, which has a certain clinical application value.