| 基于Hermia模型的中药果胶模拟体系的超滤膜过程污染机制研究 |
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| 引用本文： | 彭静,朱华旭,郭立玮,李博,茅向军.基于Hermia模型的中药果胶模拟体系的超滤膜过程污染机制研究[J].中草药,2019,50(17):4051-4059. |
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| 作者姓名： | 彭静 朱华旭 郭立玮 李博 茅向军 |
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| 作者单位： | 贵州医科大学, 贵州 贵阳 550025;南京中医药大学 江苏省中药资源产业化过程协同创新中心, 江苏 南京 210023;南京中医药大学 江苏省植物药深加工工程研究中心, 江苏 南京 210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心, 江苏 南京 210023;南京中医药大学 江苏省植物药深加工工程研究中心, 江苏 南京 210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心, 江苏 南京 210023;南京中医药大学 江苏省植物药深加工工程研究中心, 江苏 南京 210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心, 江苏 南京 210023;南京中医药大学 江苏省植物药深加工工程研究中心, 江苏 南京 210023,贵州省食品药品检验所, 贵州 贵阳 550004 |
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| 基金项目： | 国家自然科学基金项目（81473317）；国家自然科学基金项目（81673610）；国家自然科学基金项目（81773912）；国家自然科学基金项目（81873015） |
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| 摘 要： | 目的揭示有关中药提取物中果胶引起的膜污染复杂现象的机制,并探讨Hermia模型在研究中药污染机制方面的适应性。方法以中药提取液中的果胶、果胶和小分子药效物质(小檗碱)模拟溶液为研究对象,收集膜过程中通量数据,运用Hermia数学模型进行曲线拟合,分析污染机制。结果结合数学模型和扫描电子显微镜(SEM)等手段对果胶模拟溶液体系进行研究,发现膜表面滤饼层的形成是导致通量降低和膜污染的主要原因。结论 Hermia数学模型可作为分析中药提取液膜污染机制的方法,可为中药提取液超滤过程所引起的膜污染复杂现象提供理论基础。
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| 关 键 词： | 超滤 Hermia数学模型 果胶 膜污染机制 中药提取液 小檗碱 膜通量 |
| 收稿时间： | 2019/8/12 0:00:00 |
Fouling mechanisms of ultrafiltration membranes fouled with traditional Chinese medicine pectin based on Hermia model |
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| PENG Jing,ZHU Hua-xu,GUO Li-wei,LI Bo and MAO Xiang-jun.Fouling mechanisms of ultrafiltration membranes fouled with traditional Chinese medicine pectin based on Hermia model[J].Chinese Traditional and Herbal Drugs,2019,50(17):4051-4059. |
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| Authors: | PENG Jing ZHU Hua-xu GUO Li-wei LI Bo and MAO Xiang-jun |
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| Institution: | Guizhou Medical University, Guiyang 550025, China;Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210023, China,Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210023, China,Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210023, China,Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210023, China and Guizhou Institute for Food and Drug Inspection, Guiyang 550004, China |
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| Abstract: | Objective To provide fundamental information regarding the complex phenomena of membrane fouling caused by the pectin in traditional Chinese medicine extracts and investigate the accuracy and viability of the Hermia model in the determination of fouling mechanisms. Methods The pectin and simulated solutions of pectin and small molecular pharmacodynamic substances (berberine) in Chinese herbal extracts were used as the object of study. The Hermia model was used to study the fouling mechanism according to the flux changes in the membrane process. Results The pectin simulated solutions were researched by mathematical model and scanning electronic microscopy (SEM). The result showed that the formation of the cake layer was the main cause of flux decrease and membrane fouling. Conclusion Hermia model can be used as a method to study the membrane fouling mechanism of traditional Chinese medicine extracts, which can provide basic information for the complex phenomenon of membrane fouling caused by ultrafiltration of Chinese herbal medicine aqueous extracts. |
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| Keywords: | ultrafiltration Hermia mathematical model pectin fouling mechanism Chinese medicine extracts berberine membrane flux |
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