西黄胶囊联合培美曲塞治疗晚期结肠癌的临床研究

目的研究西黄胶囊联合注射用培美曲塞二钠治疗晚期结肠癌的临床疗效。方法选取2017年5月—2018年5月天津市宁河区医院收治的70例晚期结肠癌患者为研究对象,将所有患者采用随机对照法分为对照组和治疗组,每组各35例。对照组患者静脉滴注注射用培美曲塞二钠500 mg/m~2,每21天给予1次;治疗组在对照组治疗的基础上口服西黄胶囊,4粒/次,2次/d。21 d为1个治疗疗程,两组患者均接受治疗2个疗程。观察两组的临床疗效,比较两组的KPS评分、视觉模拟评分法(VAS)评分、肿瘤标志物水平和不良反应。结果治疗后,对照组和治疗组的客观缓解率(ORR)分别为60.00%、74.29%,疾病控制率(CBR)分别为74.29%、85.71%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者KPS评分显著升高,VAS评分显著降低,同组治疗前后比较差异有统计学意义(P0.05);并且治疗组患者KPS评分和VAS评分明显优于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组患者糖抗原199(CA-199)、癌胚抗原(CEA)水平均显著降低,同组治疗前后比较差异有统计学意义(P0.05);并且治疗组患者CA-199和CEA水平明显低于对照组,两组比较差异有统计学意义(P0.05)。治疗后,治疗组患者恶心呕吐、腹泻腹痛、白细胞计数下降和肝功能异常发生率显著低于对照组,两组比较差异有统计学意义(P0.05)。结论西黄胶囊联合注射用培美曲塞二钠治疗晚期结肠癌具有较好的临床疗效,可提高患者生活质量,降低疼痛和肿瘤标志物水平,安全性较高,具有一定临床推广应用价值。

Clinical study on Xihuang Capsules combined with pemetrexed in treatment of advanced colon cancer

Objective To study the efficacy of Xihuang Capsules combined with Pemetrexed Disodium for injection in treatment of advanced colon cancer. Methods Patients (70 cases) with advanced colon cancer in Tianjin Ninghe Hospital from May 2017 to May 2018 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were iv administered with Pemetrexed Disodium for injection, 500 mg/m², once every 21 d. Patients in the treatment group were po administered with Xihuang Capsules on the basis of the control group, 4 grains/time, twice daily. A course had 21 d, and patients in two groups were treated for 2 courses. After treatment, the clinical efficacies were evaluated, and KPS score, VAS score, tumor markers level, and adverse reactions in two groups were compared. Results After treatment, the ORR in the control and treatment groups were 60.00% and 74.29%, and the CBR in the control and treatment groups were 74.29% and 85.71%, respectively, and there was difference between two groups (P<0.05). After treatment, KPS scores in two groups were significantly increased, but VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CA-199 and CEA in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the tumor markers levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the incidences of nausea, vomiting, diarrhea, abdominal pain, decreased white blood cell count, and abnormal liver function in the treatment group were lower than those in the control group, and there was difference between two groups (P<0.05). Conclusion Xihuang Capsules combined with Pemetrexed Disodium for injection has clinical curative effect in treatment of advanced colon cancer, can improve the quality of life of patients, and reduce pain and the level of tumor markers, with good safety, which has a certain clinical application value.