| 疏风解毒胶囊疏风解表的谱效关系研究 |
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| 引用本文： | 韩彦琪,曹勇,董亚楠,武琦,许浚,葛德助,龚苏晓,张洪兵,张铁军,刘昌孝. 疏风解毒胶囊疏风解表的谱效关系研究[J]. 中草药, 2019, 50(15): 3534-3540 |
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| 作者姓名： | 韩彦琪 曹勇 董亚楠 武琦 许浚 葛德助 龚苏晓 张洪兵 张铁军 刘昌孝 |
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| 作者单位： | 天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,安徽济人药业有限公司, 安徽 亳州 236800,银川市中医医院, 宁夏 银川 750001,天津医科大学, 天津 300070,天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,安徽济人药业有限公司, 安徽 亳州 236800,天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193;天津药物研究院 新药评价中心, 释药技术与药代动力学国家重点实验室, 天津 300193 |
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| 基金项目： | 国家中药标准化专项资助项目（ZYBZH-C-AH-02）；国家自然科学基金资助项目（81430096）；国家自然科学基金资助项目（81703802） |
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| 摘 要： | 目的明确疏风解毒胶囊发挥疏风解表作用的潜在物质基础。方法利用LC-MS建立疏风解毒胶囊22个不同中材配比样品的MS谱库;采用与疏风解表相关的M3型乙酰胆碱受体高表达的中国仓鼠卵巢癌细胞CHO-K1/M3为体外中效筛选模型,检测22个样品对M3受体的激动活性;以22个样品特征峰的相对峰面积为自变量,以对M3受体的激动率为因变量,采用BP-神经网络算法进行谱-效关联分析。结果通过建立的最佳神经网络模型,计算得到16个特征峰与疏风解毒胶囊对M3受体的激动活性显著相关。结论通过谱效研究,推测疏风解毒胶囊发挥疏风解表的中效物质基础可能为包括二氢败酱苷、大黄素、大黄酸、连翘苷、连翘酯苷E、柴胡皂苷d、虎杖苷、毛蕊花糖苷等在内的16个化合物,为其质量标志物的确定提供了依据。
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| 关 键 词： | 疏风解毒胶囊 清热解毒 谱效关系 神经网络 二氢败酱苷 大黄素 大黄酸 连翘苷 连翘酯苷E 柴胡皂苷d 虎杖苷 毛蕊花糖苷 |
| 收稿时间： | 2019-03-15 |
Spectrum-effect relationship of wind-dispersing and exterior syndrome-relieving of Shufeng Jiedu Capsules |
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| HAN Yan-qi,CAO Yong,DONG Ya-nan,WU Qi,XU Jun,GE De-zhu,GONG Su-xiao,ZHANG Hong-bing,ZHANG Tie-jun and LIU Chang-xiao. Spectrum-effect relationship of wind-dispersing and exterior syndrome-relieving of Shufeng Jiedu Capsules[J]. Chinese Traditional and Herbal Drugs, 2019, 50(15): 3534-3540 |
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| Authors: | HAN Yan-qi CAO Yong DONG Ya-nan WU Qi XU Jun GE De-zhu GONG Su-xiao ZHANG Hong-bing ZHANG Tie-jun LIU Chang-xiao |
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| Affiliation: | National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Anhui Jiren Pharmaceutical Co., Ltd., Bozhou 236800, China,Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan 750001, China,Tianjin Medical University, Tianjin 300070, China,National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Anhui Jiren Pharmaceutical Co., Ltd., Bozhou 236800, China,National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China and Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Center for New Drug Evaluation and Research, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | |
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| Keywords: | Shufeng Jiedu Capsule wind-dispersing and exterior syndrome-relieving spectrum-effect relationship neural network dihydrodylate glycoside emodin rhein phillyrin forsythoside E saikosaponin d polydatin verbascoside |
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