2型糖尿病患者糖尿病性视网膜病变和骨密度相关性的研究

目的：探索2型糖尿病患者糖尿病性视网膜病变(DR)和骨密度(BMD)之间的关系，为DR患者骨质疏松的防治提供依据。

方法：采用前瞻性、对照研究，对2018-01/09就诊于我院眼科和内分泌科的自愿参与研究的2型糖尿病患者101例和非糖尿病患者17例进行研究，记录患者一般信息、腰椎骨密度(LB)、髋关节骨密度(HB)结果和实验室检查结果，进行分析。

结果：对于糖尿病患者，HB与DR程度呈负相关(r=-0.23，P=0.02)。按性别分组对骨密度与DR程度进一步分析，男性患者LB和HB组间无差异； 女性患者LB和HB组间有差异(F=3.52，P=0.02； F=5.21，P<0.05)，女性患者伴随DR的发展，LB和HB均呈下降趋势。

结论：女性2型糖尿病伴有DR患者骨密度降低较明显，在治疗基础疾病的同时应注意对骨质疏松进行积极干预，降低骨折风险。

Correlation between diabetic retinopathy and bone mineral density in type 2 diabetic patients

AIM: To explore the relationship between diabetic retinopathy(DR)and bone mineral density(BMD)in type 2 diabetic patients, and to provide evidence for the prevention and treatment of osteoporosis in diabetic retinopathy patients.

METHODS: A prospective, controlled study was conducted on 101 type 2 diabetic patients and 17 non-diabetic patients who visited the Department of Ophthalmology and Endocrinology of Huangshi Central Hospital from January 2018 to September 2018. General information, BMD results(LB, HB), and laboratory results were recorded for analysis.

RESULTS: In patients with diabetes, HB was negatively correlated with the severity of DR(r=-0.23, P=0.02). Further analysis of BMD and severity of DR was performed by gender grouping. There was no statistically significant difference between LB and HB groups in male patients. There were statistically significant differences between the LB and HB groups in female patients(F=3.52, P=0.02; F=5.21, P<0.05). In female patients with type 2 diabetes, both LB and HB showed a declining trend with the development of DR.

CONCLUSION: In women with type 2 diabetes mellitus accompanied by DR, the bone mineral density decreased significantly. In the treatment of basic diseases, active intervention for osteoporosis should be paid attention to reduce the risk of fracture.