地黄叶总苷胶囊联合吗替麦考酚酯治疗肾病综合征的临床效果研究

目的 研究地黄叶总苷胶囊联合吗替麦考酚酯分散片治疗肾病综合征的临床效果。方法 本研究选择2015年1月-2017年12月榆林市第二医院收治的肾病综合征患者102例为研究对象，根据随机数字表法将患者随机分为对照组（51例）和观察组（51例）。对照组口服吗替麦考酚酯分散片治疗，1.0 g/次，2次/d。观察组患者在对照组基础上口服地黄叶总苷胶囊，0.4 g/次，2次/d。两组的治疗疗程均为8周。观察两组的临床疗效，同时比较两组的肾功能、血液流变学指标以及免疫功能。结果 观察组的总有效率为92.16%，明显高于对照组的76.47%（P<0.05）。治疗后，两组患者的尿素氮（BUN）、24 h尿蛋白定量及肌酐（Scr）水平均明显降低（P<0.05），且观察组肾功能指标明显低于对照组（P<0.05）。治疗后，两组的血黏稠度及血小板聚集率均明显降低（P<0.05）；且观察组明显低于对照组（P<0.05）。治疗后，两组患者的CD4⁺/CD8⁺以及CD4⁺均明显升高，CD8⁺明显降低（P<0.05）；且观察组免疫功能明显优于对照组（P<0.05）。结论 地黄叶总苷胶囊联合吗替麦考酚酯分散片治疗肾病综合征的疗效确切，能有效改善患者的肾功能、血液流变学以及免疫功能，值得临床推广使用。

Clinical effect of Dihuangye Total Glycosides Capsules combined with mycophenolate mofetil in treatment of nephrotic syndrome

Objective To investigate the clinical effect of Dihuangye Total Glycosides Capsules combined with Mycophenolate mofetil Dispersible Tablets in treatment of nephrotic syndrome. Methods 102 cases of patients with nephrotic syndrome in The Second Hospital of Yulin from January 2015 to December 2017, were randomly divided into control group (51 cases) and observation group (51 cases). Patients in the control group were po administered with Mycophenolate mofetil Dispersible Tablets, 1.0 g/time, twice daily. Patients in the observation group were po administered with Dihuangye Total Glycosides Capsules on the basis of control group, 0.4 g/time, twice daily. Patients in two groups were treated for 8 weeeks. After treatment, the clinical efficacy was evaluated, and renal function, hemorheology indexes, and immune function of the two groups were compared. Results After treatment, the effective rate in the observation group was 92.16%, which was significantly higher than 76.47% in the control group (P<0.05). After treatment, the levels of BUN, 24 h urine protein, and Scr were significantly decreased, (P<0.05), and the renal function indexes in the observation group was significantly lower than those in the control group (P<0.05). After treatment, blood viscosity and platelet aggregation rate in two groups were significantly decreased (P<0.05), and the observation group was significantly lower than control group (P<0.05). After treatment, the CD4⁺/CD8⁺ and CD4⁺ of the two groups were increased significantly, while CD8⁺ decreased significantly (P<0.05), and the immune function indexes in the observation group was more better than control group (P<0.05). Conclusion Dihuangye Total Glycosides Capsules combined with Mycophenolate mofetil Dispersible Tablets has a definite curative effect on nephrotic syndrome. It can effectively improve the renal function, hemorheology and immune function of patients. It is worthy of clinical application.