| 小檗属植物抗糖尿病及糖尿病并发症的研究进展 |
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| 引用本文： | 廖翠平,赵鹿,董世奇,侯文彬,樊慧蓉. 小檗属植物抗糖尿病及糖尿病并发症的研究进展[J]. 现代药物与临床, 2019, 42(5): 1027-1032 |
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| 作者姓名： | 廖翠平 赵鹿 董世奇 侯文彬 樊慧蓉 |
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| 作者单位： | 天津中医药大学, 天津 301617;中国医学科学院放射医学研究所, 天津 200192;天津药物研究院, 天津 300301,天津中医药大学, 天津 301617,中国医学科学院放射医学研究所, 天津 200192,天津药物研究院, 天津 300301,中国医学科学院放射医学研究所, 天津 200192 |
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| 摘 要： | 小檗属植物资源丰富，药用历史悠久，可用于治疗多种疾病，其中刺檗、具芒小檗、毛叶黄耆和豪猪刺等植物的研究较为深入。小檗属植物的主要成分为生物碱类和黄酮类，研究最多的是小檗碱，其具有降血糖血脂、抗炎、抑菌等药理作用，可用于治疗糖尿病及其并发症。然而，对小檗碱的研究并不能代替对小檗属植物的研究。对小檗属植物提取物抗糖尿病及其并发症的药理作用和作用机制进行综述，为促进该属植物及其有效成分的临床应用提供理论基础。
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| 关 键 词： | 小檗属植物 小檗皮 刺檗 小檗碱 药理作用 糖尿病及并发症 |
| 收稿时间： | 2018-12-04 |
Research advances on anti-diabetes and complications of Berberis plants |
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| LIAO Cuiping,ZHAO Lu,DONG Shiqi,HOU Wenbin and FAN Huirong. Research advances on anti-diabetes and complications of Berberis plants[J]. Drugs & Clinic, 2019, 42(5): 1027-1032 |
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| Authors: | LIAO Cuiping ZHAO Lu DONG Shiqi HOU Wenbin FAN Huirong |
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| Affiliation: | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;Institute of Radiation Medicine Chinese Academy of Medical Sciences, Tianjin 200192, China;Tianjin Institute of pharmaceutical research, Tianjin 300301, China,Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China,Institute of Radiation Medicine Chinese Academy of Medical Sciences, Tianjin 200192, China,Tianjin Institute of pharmaceutical research, Tianjin 300301, China and Institute of Radiation Medicine Chinese Academy of Medical Sciences, Tianjin 200192, China |
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| Abstract: | Berberis plants are rich in resources and have a long history of medicinal use, and they can be used to treat a variety of diseases. Among them, plants such as B. integerrima, B. aristata, B. vulgaris, B. microphylla, and B. julianae are studied deeper. The main components of the genus Berberis are alkaloids and flavonoids, and the most studied agent is berberine. It has pharmacological effects such as hypoglycemic, anti-inflammatory, antibacterial, etc., which can be used to treat diabetes and its complications. However, the study of berberine is not a substitute for the study of Berberis plants. This paper summarizes the pharmacological studies and its mechanism of action on the anti-diabetes and its complications of Berberis extract, so as to provide theoretical basis for promoting the clinical application of Berberis plants and its components. |
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| Keywords: | Berberis L.plants Berberis Schneid Berberis vulgaris berberine pharmacological action diabetes and complications |
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