| 平面细胞极性在晶状体发育中的作用 |
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| 引用本文： | 陈奕嘉,李金燕,欧阳帅,罗莉霞. 平面细胞极性在晶状体发育中的作用[J]. 国际眼科杂志, 2019, 19(12): 2041-2044 |
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| 作者姓名： | 陈奕嘉 李金燕 欧阳帅 罗莉霞 |
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| 作者单位： | 中国广东省广州市,中山大学中山眼科中心 眼科学国家重点实验室,中国广东省广州市,中山大学中山眼科中心 眼科学国家重点实验室,中国广东省广州市,中山大学中山眼科中心 眼科学国家重点实验室,中国广东省广州市,中山大学中山眼科中心 眼科学国家重点实验室 |
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| 基金项目： | 国家自然科学基金项目(No.81770905) |
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| 摘 要： | 晶状体发育是一个复杂的生物学过程，受多种信号分子及其构成的通路网络调控。近年研究发现，平面细胞极性(PCP)信号通路在晶状体发育过程中起重要作用，是形成晶状体正常透明度和形态的基础。PCP的深入研究为临床治疗先天性白内障提供了指导意义，同时更是有望成为完善再生晶状体的新干预靶点。本文结合目前该领域研究进展就PCP在晶状体的发育过程中的作用进行详细综述。
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| 关 键 词： | 平面细胞极性 晶状体发育 Wnt/PCP信号通路 晶状体纤维细胞 细胞骨架 |
| 收稿时间： | 2019-03-22 |
| 修稿时间： | 2019-10-31 |
Function of planar cell polarity in lens development |
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| Yi-Jia Chen,Jin-Yan Li,Shuai Ouyang and Li-Xia Luo. Function of planar cell polarity in lens development[J]. International Eye Science, 2019, 19(12): 2041-2044 |
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| Authors: | Yi-Jia Chen Jin-Yan Li Shuai Ouyang Li-Xia Luo |
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| Affiliation: | State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510623, Guangdong Province, China,State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510623, Guangdong Province, China,State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510623, Guangdong Province, China and State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510623, Guangdong Province, China |
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| Abstract: | Regarded as a complex biological process, lens development involves a range of signal molecules and their crosstalk networks. Recently,the role of planar cell polarity(PCP)signaling pathway in lens development has attracted increasing attention. It has been reported that PCP is critical for lens morphology and transparency maintaining. The studies performed on PCP serve to provide guidelines on how to optimize the morphology of regenerated lens. This is thought as presenting an effective therapy for infant cataract from a clinical perspective. This article will give a comprehensive review of the role of PCP signaling pathways in the lens development. |
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| Keywords: | planar cell polarity lens development Wnt/PCP signaling pathway lens fiber cells cytoskeleton |
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