清淋颗粒联合硝呋太尔治疗尿路感染的临床研究

目的 探讨清淋颗粒联合硝呋太尔治疗尿路感染患者的临床效果。方法 选择2016年10月-2017年10月荆州市中心医院收治的尿路感染患者175例，随机分成对照组（87例）和治疗组（88例）。对照组患者口服硝呋太尔片，2片/次，3次/d；治疗组患者在对照组基础上口服清淋颗粒，1袋/次，2次/d。两组患者均连续治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者细菌培养转阴率、尿液肝素结合蛋白（HBP）和尿液白细胞计数（WBC）及血清IL-8和降钙素原（PCT）水平。结果 治疗后，对照组临床有效率和细菌培养转阴率分别为88.51%和83.91%，均分别显著低于治疗组的97.73%和94.32%，两组比较差异均具有统计学意义（P<0.05）。治疗后，两组尿液HBP水平、尿液WBC个数均显著降低（P<0.05），且治疗组患者两种指标明显低于对照组（P<0.05）。治疗后，两组患者血清IL-8、PCT水平显著降低（P<0.05），且治疗组患者IL-8和PCT水平明显低于对照组（P<0.05）。结论 清淋颗粒联合硝呋太尔治疗尿路感染不但可减轻患者尿道炎症水平，而且对缓解尿道不适症状作用明显，具有一定的临床推广应用价值。

Clinical study on Qinglin Granules combined with nifuratel in treatment of urinary tract infection

Objective To investigate the clinical effect of Qinglin Granules combined with nifuratel in treatment of urinary tract infection. Methods Patients (175 cases) with urinary tract infection in Jingzhou Central Hospital from October 2016 to October 2017 were randomly divided into control (87 cases) and treatment (88 cases) groups. Patients in the control group were po administered with Nifuratel Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Qinglin Granules on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the bacteria negative-converting rate, HBP and WBC of urine samples, and serum levels of IL-8 and PCT in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and the bacteria negative-converting rate in the control group were 88.51% and 83.91%, which were significantly lower than 97.73% and 94.32% in the treatment group, respectively, and there were differences between two groups (P < 0.05). After treatment, the HBP and WBC levels of urine samples in two groups were significantly decreased (P < 0.05), and these two indicators in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the serum levels of IL-8 and PCT in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Qinglin Granules combined with nifuratel in treatment of urinary tract infection can not only reduce the urinary tract inflammation level, but also has obvious effects on relieving urinary discomfort, which has a certain clinical application value.