石斛在糖尿病等代谢性疾病中的作用及机制研究进展

石斛是历代中医治疗"消渴证"的要药。近年来,随着代谢相关疾病的高发,其在防治糖尿病、高血压等相关代谢性疾病中的作用逐渐被挖掘,也越来越受到关注。综述不同石斛对糖尿病、高血压、高脂血症等相关代谢性疾病的作用及其共同作用机制,并从传统功效入手,总结提出石斛"益胃生津、滋阴清热"治疗"脾瘅——中满内热"是其改善糖尿病等相关代谢性疾病的关键,为石斛在防治糖尿病等相关代谢性疾病研究及临床应用中提供参考。

Research progress on protective effects and mechanism of Dendrobii Caulis on metabolic disturbances

Life style changes with economic and social development, including a improper diet, cause diabetes, dyslipidemia, hypertension and other metabolic disturbances, which has become a major threat to the health of people around the world. Dendrobii Caulis, a traditional Chinese herbal medicine with various medicinal and health-care effects, is derived from different species of Dendrobium, which is traditionally used for "consumptive thirst syndrom". In recent years, its preventive effects on metabolic disturbances have been attracting more and more attention with the high incidence of metabolic disturbances. This paper aims to review the recent achievements of different Dendrobium species in preventive and therapeutic effects and its traditional functions on metabolic disturbances, mainly in diabetes, hypertension and dyslipidemia. Furthermore, probable mechanisms were summarized based on its traditional functions. Dendrobii Caulis was effective on metabolic disturbances primarily relevant to its conventional functions including replenishing yin for maintaining gastric tonicity, promoting body fluid production, nourishing yin and clearing heat, which is helpful for treatment of spleen impediment with abdominal flatulence and interior heat, the source of various metabolic disturbances in traditional medicine. This review provids reference for mechanism research and clinical application of Dendrobium in metabolic disturbances prevention and treatment.