灯盏细辛注射液联合丁苯酞治疗急性脑梗死的临床研究

目的探讨灯盏细辛注射液联合丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效。方法选取2017年3月—2018年11月洛阳市第三人民医院收治的90例急性脑梗死患者为研究对象,按照随机数字表法将患者分为对照组和治疗组,每组各45例。对照组静脉滴注丁苯酞氯化钠注射液,25 mg/次,2次/d。治疗组在对照组治疗的基础上静脉滴注灯盏细辛注射液,30 mL加入到250 mL生理盐水中充分稀释,30 mL/次,1次/d。两组患者均连续治疗14 d。观察两组患者的临床疗效,同时比较两组治疗前后的神经功能缺损评分(NIHSS)、日常生活活动能力评定量表(ADL)评分和血管内皮功能指标。结果治疗后,对照组和治疗组的总有效率分别为75.56%、91.11%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组NIHSS评分显著降低,ADL评分显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组NIHSS评分显著低于对照组,ADL评分显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组的内皮素-1(ET-1)、血管生成素(Ang-1)、血管内皮生长因子(VEGF)水平明显降低,一氧化氮(NO)明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组血管内皮功能指标水平显著优于对照组,两组比较差异具有统计学意义(P<0.05)。结论灯盏细辛注射液联合丁苯酞氯化钠注射液治疗急性脑梗死具有较好的临床疗效,能改善患者的神经功能和血管内皮功能指标,具有一定的临床推广应用价值。

Clinical study on Dengzhanxixin Injection combined with butylphthalide in treatment of acute cerebral infarction

Objective To investigate the clinical efficacy of Dengzhanxixin Injection combined with Butylphthalide and Sodium Chloride Injection in treatment of acute cerebral infarction. Methods Patients (90 cases) with acute cerebral infarction in Luoyang Third People''s Hospital from March 2017 to November 2018 were randomly divided into control and treatment groups, and each group had 45 cases. Patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 25 mg/time, twice daily. Patients in the treatment group were iv administered with Dengzhanxixin Injection on the basis of the control group, 30 mL added into normal saline 250 mL, 30 mL/time, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the NIHSS scores, ADL scores, and vascular endothelial function indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 75.56% and 91.11%, respectively, and there were differences between two groups (P < 0.05). After treatment, NIHSS scores in two groups were significantly decreased, but ADL scores were significantly increased, and the difference was statistically significant in the same group (P< 0.05). After treatment, NIHSS scores in the treatment group were significantly lower than those in the control group, but the ADL scores were significantly higher than those in the control group, with significant difference between two groups (P< 0.05). After treatment, ET-1, Ang-1, and VEGF levels in two groups were significantly decreased, but NO levels in two groups were significantly increased, and the difference was statistically significant in the same group (P< 0.05). After treatment, the vascular endothelial function indexes levels in the treatment group were significantly better than those in the control group,with significant difference between two groups (P< 0.05). Conclusion Dengzhanxixin Injection combined with Butylphthalide and Sodium Chloride Injection has clinical curative effect in treatment of acute cerebral infarction, can improve the neurological function and vascular endothelial function, which has a certain clinical application value.