血清胆碱酯酶活性测定对肝硬化Child-Pugh分级的临床价值

目的研究胆碱酯酶（CHE）在肝硬化Child-Pugh分级中的临床价值。方法将82例肝硬化患者按照Chi｜d-Pugh分级标准分为A、B、C3级，另选衡阳市中心医院体检中心健康体检者32例作为健康对照组，分剐检测CHE活性及血清清蛋白（Alb）水平，并对结果作相关统计学分析。结果肝硬化患者CHE活性较健康对照组有明显降低，差异有统计学意义（P〈O．01），且各级之闯差异有统计学意义（P〈0．01），各级肝硬化患者CHE活性降低程度与Alb降低程度呈现明显正相关（r=0．72）。结论血清CHE活性和Alb浓度一样能较好地反映肝硬化患者的Child—Pugh分级情况，但Alb水平易受外源性输注Alb等其他因素的影响，血清CHE较Alb能更准确地反映肝硬化患者的Child-Pugh分级情况，对及时准确地评估肝硬化患者的Child—Pugh分级情况以及肝脏的储备功能有重要的指导意义，可用于替代Alb作为肝硬化分级及手术预后的指标，值得临床应用。

Clinical value of detection of serum cholinesterase in Child-Pugh classification of the patients with cirrhosis

Objective To investigate the clinical value of serum eholinesterase（CHE） of Child-Pugh classification in the patients with cirrhosis. Methods 82 patients with cirrhosis were divided into A.B.C level according to Child-Pugh classification,and 32 people who had healthy physic examination in our experience center were selected as the normal control group, the levels of serum CHE and albumin （Alb） were detected separately,and the results were analyzed with relevant statistics. Results The levels of serum CHE of patients with cirrhosis is obviously lower than that of the healthy control group,and the difference is very prominent （P〈0.01）. And each stages of all the levels also has the significance difference （P〈0.01）, There was positive correlation between CHE activity and Alb concentration （r=0.72）. Conclusion Serum CHE activity and Alb concentration can well equally reflect the situation of Child-Pugh classification of patients with cirrhosis, however,The level of serum Alb was affected by the exogenous infusion of Alb and other factors, therefore this article believes that serum CHE can reflect the situation of Child- Pugh classification of patients with cirrhosis more accurately than Alb,and it is importance to guide in assessing the situation of Child-Pugh classification of patients with cirrhosis and to help recover the function of liver accurately in time. It can be used for substituting the Alb as the index of grading the situation of Child-Pugh classification of patients with cirrhosis and the prognosis of operation. So it is worth being popularized clinically.