| 动态观察外周血单个核细胞中乙型肝炎病毒DNA变化与干扰素治疗应答的关系 |
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| 引用本文： | 戴炜,冯筱榕,郭亚兵. 动态观察外周血单个核细胞中乙型肝炎病毒DNA变化与干扰素治疗应答的关系[J]. 实用肝脏病杂志, 1999, 0(2) |
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| 作者姓名： | 戴炜 冯筱榕 郭亚兵 |
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| 作者单位： | 深圳市东湖医院，第一军医大学南方医院，第一军医大学南方医院 518020 |
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| 摘 要： | 应用聚合酶链反应(PCR)方法动态检测PBMC中HBV DNA,研究6例干扰素治疗的慢性乙型肝炎患者的疗效。血清中HBV DNA在治疗平均5周(3～10周)转阴。5例PBMC中HBV DNA平均15周(12～20周)阴转,1例始终阳性,并出现转氨酶反跳。α干扰素能清除PBMC中HBV DNA,但较血清中HBV DNA清除延迟;PBMC中HBVDNA持续阳性意味着干扰素治疗疗效差。
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| 关 键 词： | 乙型肝炎 干扰素 外周血单个核细胞 HBV DNA |
DYNAMIC ANALYSIS OF HEPATITIS B VIRUS DNA IN PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH HEPATITIS B TREATED WITH INTERFERON ALFA |
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| Dai Wei,Feng Xiaorong,Guo Yabing. DYNAMIC ANALYSIS OF HEPATITIS B VIRUS DNA IN PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH HEPATITIS B TREATED WITH INTERFERON ALFA[J]. Journal of Clinical Hepatology, 1999, 0(2) |
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| Authors: | Dai Wei Feng Xiaorong Guo Yabing |
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| Affiliation: | Dai Wei,Feng Xiaorong,Guo Yabing. Department of Infectious Disease,Nanfang Hospital,Guangzhou,510515 |
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| Abstract: | Six patients with chronic active hepatitis B were investigated for HBV DNA both in sera and in peripheral blood mononuclear cells (PBMCs) by polymerase chain reaction (PCR) before, during and after interferon (IFN) alfa treatment. All patients were responded to IFN therapy with remission of serum alanine aminotransminase. HBV DNA disappeared in six sera and in five PBMCs during the treatment. The average eliminating period of HBV DNA was 5 weeks (3 to 10 weeks)in serum and 15 weeks (12 to 20 weeks)in PBMCs. Relapse of serum ALT elevation was seen in one patient with persistently positive of HBV DNA in PBMCs during and after interferon treatment. Results show that clearance of HBV DNA in PBMCs is more difficult than that in sera,and that the existence of HBV DNA in PBMCs after IFN alfa treatment means the failure of IFN therapy in hepatitis B virus infection. |
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| Keywords: | Hepatitis B Interferon Peripheral Blood Mononuclear Cells HBV DNA |
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